ENTRY D00109 Drug NAME Aspirin (JP18/USP); Aspalon (JAN); Acetylsalicylic acid; Easprin (TN); Durlaza (TN) FORMULA C9H8O4 EXACT_MASS 180.0423 MOL_WEIGHT 180.16 CLASS Blood modifier agent DG01950 Antithrombotic agent DG01712 Antiplatelet agent Anti-inflammatory DG01504 Nonsteroidal anti-inflammatory drug (NSAID) DG01909 Anti-inflammatory drug, salicylic acid derivatives REMARK Same as: C01405 Therapeutic category: 1143 3399 ATC code: A01AD05 B01AC06 N02BA01 Chemical structure group: DG00015 Product (DG00015): D00109 Product (mixture): D03960 D10513 D10527 D11176 D11615 D11804 D11849 D11859 D11860 EFFICACY Analgesic, Anti-inflammatory, Antipyretic, Antirheumatic, Antiplatelet, COX inhibitor DISEASE Myocardial infarction [DS:H01730] Unstable angina pectoris [DS:H01632] Chronic stable angina [DS:H01632] COMMENT Salicylic acid derivative TARGET PTGS1 (COX1) [HSA:5742] [KO:K00509] PTGS2 (COX2) [HSA:5743] [KO:K11987] PATHWAY hsa00590(5742+5743) Arachidonic acid metabolism hsa04611(5742) Platelet activation INTERACTION STR_MAP map07048 Antimigraines map07049 Antithrombosis agents map07110 Benzoic acid family map07219 Cyclooxygenase inhibitors BRITE Anatomical Therapeutic Chemical (ATC) classification [BR:br08303] A ALIMENTARY TRACT AND METABOLISM A01 STOMATOLOGICAL PREPARATIONS A01A STOMATOLOGICAL PREPARATIONS A01AD Other agents for local oral treatment A01AD05 Acetylsalicylic acid D00109 Aspirin (JP18/USP) <JP> B BLOOD AND BLOOD FORMING ORGANS B01 ANTITHROMBOTIC AGENTS B01A ANTITHROMBOTIC AGENTS B01AC Platelet aggregation inhibitors excl. heparin B01AC06 Acetylsalicylic acid D00109 Aspirin (JP18/USP) <JP> N NERVOUS SYSTEM N02 ANALGESICS N02B OTHER ANALGESICS AND ANTIPYRETICS N02BA Salicylic acid and derivatives N02BA01 Acetylsalicylic acid D00109 Aspirin (JP18/USP) <JP> USP drug classification [BR:br08302] Blood Products and Modifiers Platelet Modifying Agents Platelet Modifying Agents, Other Aspirin D00109 Aspirin (JP18/USP) Therapeutic category of drugs in Japan [BR:br08301] 1 Agents affecting nervous system and sensory organs 11 Agents affecting central nervous system 114 Antipyretics and analgesics, anti-inflammatory agents 1143 Salicylates D00109 Aspirin (JP18/USP); Aspalon (JAN) 3 Agents affecting metabolism 33 Blood and body fluid agents 339 Miscellaneous 3399 Others D00109 Aspirin (JP18/USP); Aspalon (JAN) Classification of Japanese OTC drugs [BR:br08313] Agents for nervous and sensory systems 01 Cold remedy (oral use) D00109 Aspirin (JP18/USP) 03 Antipyretic analgesic agents D00109 Aspirin (JP18/USP) Risk category of Japanese OTC drugs [BR:br08312] Designated second-class OTC drugs Inorganic and organic chemicals Aspirin D00109 Aspirin (JP18/USP) Second-class OTC drugs Inorganic and organic chemicals Aspirin D00109 Aspirin (JP18/USP) Drug groups [BR:br08330] Blood modifier agent DG01950 Antithrombotic agent DG01712 Antiplatelet agent DG00015 Acetylsalicylic acid D00109 Aspirin Anti-inflammatory DG01504 Nonsteroidal anti-inflammatory drug (NSAID) DG01909 Anti-inflammatory drug, salicylic acid derivatives DG00015 Acetylsalicylic acid D00109 Aspirin Drug classes [BR:br08332] Anti-inflammatory DG01504 Nonsteroidal anti-inflammatory drug (NSAID) D00109 Aspirin Target-based classification of drugs [BR:br08310] Enzymes Oxidoreductases (EC1) Prostaglandin synthase PTGS1 (COX1) D00109 Aspirin (JP18/USP) <JP> PTGS2 (COX2) D00109 Aspirin (JP18/USP) <JP> Drugs listed in the Japanese Pharmacopoeia [BR:br08311] Chemicals D00109 Aspirin D00109 Aspirin tablets Rx-to-OTC switch list in the USA [br08315.html] D00109 Drug groups [BR:br08330] Blood modifier agent DG01950 Antithrombotic agent DG01712 Antiplatelet agent DG00015 Acetylsalicylic acid Anti-inflammatory DG01504 Nonsteroidal anti-inflammatory drug (NSAID) DG01909 Anti-inflammatory drug, salicylic acid derivatives DG00015 Acetylsalicylic acid DBLINKS CAS: 50-78-2 PubChem: 7847177 ChEBI: 15365 PDB-CCD: AIN LigandBox: D00109 NIKKAJI: J2.300K ATOM 13 1 C8y C 20.2981 -15.8105 2 C8y C 21.5226 -16.5029 3 C8x C 19.0928 -16.5029 4 C6a C 20.2981 -14.6227 5 C8x C 21.5226 -17.9133 6 O7a O 22.7278 -15.8040 7 C8x C 19.0928 -17.9133 8 O6a O 21.5033 -13.9240 9 O6a O 19.0863 -13.9304 10 C8x C 20.2981 -18.6250 11 C7a C 23.9396 -16.4964 12 C1a C 25.1450 -15.7977 13 O6a O 23.9396 -17.8942 BOND 13 1 1 2 1 2 1 3 2 3 1 4 1 4 2 5 2 5 2 6 1 6 3 7 1 7 4 8 1 8 4 9 2 9 5 10 1 10 6 11 1 11 11 12 1 12 11 13 2 13 7 10 2 ///