1: A2M alpha-2-macroglobulin[Homo sapiens] Gene ID: 2, updated on 11-May-2012 SUMMARY ------------------------------------------------------------------------------------------------- Official Symbol: A2M (provided by HGNC) Official full name: alpha-2-macroglobulin (provided by HGNC) Primary source: HGNC:7 See related: Ensembl:ENSG00000175899; HPRD:00072; MIM:103950; Vega:OTTHUMG00000150267 Gene type: protein coding RefSeq status: REVIEWED Organism: Homo sapiens Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as: A2MD; CPAMD5; FWP007; S863-7; DKFZp779B086 Summary: Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq, Jul 2008]
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Genomic context

Location :
12p13.31
See A2M in MapViewer

Chromosome 12 - NC_000012.11Genomic Context describing neighboring genes Neighboring gene voltage-dependent anion channel 2 pseudogene 2 Neighboring gene chromosome 12 open reading frame 33 Neighboring gene uncharacterized LOC144571 Neighboring gene keratin 17 pseudogene Neighboring gene B-cell translocation gene 1 pseudogene 1

Related Articles in PubMed 1. Diagnostic value of multiple biomarker panel for prediction of significant fibrosis in chronic hepatitis C. Park SH, . Clin Biochem, 2011 Dec, PMID 21971609. 2. A directed protein interaction network for investigating intracellular signal transduction. Vinayagam A, . Sci Signal, 2011 Sep 6, PMID 21900206. 3. During glaucoma, alpha2-macroglobulin accumulates in aqueous humor and binds to nerve growth factor, neutralizing neuroprotection. Bai Y, . Invest Ophthalmol Vis Sci, 2011 Jul, PMID 21642630. 4. Characterization of a novel positive transcription regulatory element that differentially regulates the alpha-2-macroglobulin gene in replicative senescence. Li R, . Biogerontology, 2011 Dec, PMID 21541797. 5. Inhibition of beta2-microglobulin amyloid fibril formation by alpha2-macroglobulin. Ozawa D, . J Biol Chem, 2011 Mar 18, PMID 21216953. 6. Exploration of genetic susceptibility factors for Parkinson's disease in a South American sample. Benitez BA, . J Genet, 2010 Aug, PMID 20861575. GeneRIFs: Gene References Into Functions 1. We observed that the most informative biomarkers for predicting significant liver fibrosis in chronic hepatitis C patients were blood levels of alpha2-macroglobulin and hyaluronic acid 2. Identify a novel transcriptional regulatory element contributing to the up-regulation of alpha2M during replicative senescence. 3. alpha2-macroglobulin is neurotoxic by inhibiting neuroprotective activity of nerve growth factor via TrkA receptors. 4. dimeric alpha2M as well as tetrameric alpha2M may play an important role in controlling beta2-m amyloid fibril formation 5. The extracellular chaperone alpha-2-macroglobulin is likely to help control amyloid formation and toxicity in vivo 6. The chaperone action of alpha-2-macroglobulin inhibits the toxicity and uptake of A beta in human cerebrospinal fluid 7. The chaperone action of alpha-2-macroglobulin targets prefibrillar species to inhibit amyloid formation 8. Alpha-2-macroglobulin is an extracellular chaperone 9. statistically significant evidence of interaction between the polymorphisms in A2M, SLC6A4 and UCHL1 genes (global P = 0.0107, for the best model) and the risk for PD. 10. LRP1-C/T, A2M-Ile/Val and APOE-epsilon 2/epsilon 3/epsilon 4 polymorphisms are associated with AD. 11. Reduced expression of alpha-2 macroglobulin and complement factor B was detected in sera of patients with nasopharyngeal carcinoma. 12. Haplotype -88G/25G might play a protective role in the development of SAD, and the protective effects of -88G and 25G were independent of APOEvarepsilon4 allele. 13. Galectin-3 Binding Protein and Alpha-2 macroglobulin were differentially expressed on DVT patients in microparticles extracted from platelet-poor plasma 14. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) 15. SP-D utilizes a novel mechanism in which the collectin interacts with protease inhibitor A2M to decrease its degradation and to concurrently increase its innate immune function. 16. These data support an involvement of the suggested A2M risk haplotype in the pathogenesis of Alzheimer's disease and adds new evidence to the risk-allele depletion hypothesis. 17. LRP1 bound A2M* found to be associated with an inhibition of tumor cell proliferation, migration, invasion, spheroid formation, and anchorage-independent growth. 18. A2M allele and genotype frequencies were similar between AD patients and controls. 19. An ancestral risk haplotype clade in ACE and putative multilocus association between ACE, A2M, and LRRTM3 in Alzheimer disease. 20. Results of this study revealed no association between the I1000V polymorphism of A2M and Chinese sporadic AD in Guangzhou and Chengdu. 21. both alpha(2)M and Hp are likely to play an important role in controlling the inappropriate aggregation of proteins in the extracellular environment. 22. Copper is taken up efficiently from albumin and alpha2-macroglobulin by cultured human cells by more than one mechanism. 23. effects of intact alpha(2)M on cell physiology reflect the degree of penetration of activities associated with different domains 24. Senile systemic amyloidosis was associated with age, myocardial infarctions, the G/G (Val/Val) genotype of the exon 24 polymorphism in the alpha2-macroglobulin (alpha2M), and the H2 haplotype of the tau gene 25. Alpha 2M activated by neutrophil elastase to its receptor-recognized form binds CpG ODN and enhances their immunostimulatory properties significantly. 26. alpha2M is a newly discovered and unique member of a small group of abundant extracellular proteins with chaperone properties 27. Observational study and meta-analysis of gene-disease association. (HuGE Navigator) 28. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) 29. Observational study of gene-disease association. (HuGE Navigator) 30. Decreased expression of alpha2-M mRNA and protein and protease inhibitory activity in the vaginal wall tissues of women with stress urinary incontinence(SUI) may contribute to the development of SUI. 31. expression and characterization of three alpha(2)M domains predicted to be involved in the stabilization of the thiol ester in native alpha2M and in its activation upon bait region proteolysis. 32. alpha2-macroglobulin may facilitate conformational changes in prion protein in spontaneous forms of prion disease 33. These results suggest the possible involvement of cathepsin E in disruption of the structural and functional integrity of alpha 2-macroglobulin in the endolysosome system. 34. has an important role in the AD-specific neurodegenerative process but its exon 24 Val-1000-Ile polymorphism is not likely to be associated with late-onset sporadic AD in the Hungarian population 35. increased alpha(2)-macroglobulin expression appears to be associated with benign prostatic hyperplasia 36. distinct binding sites mediate interaction with beta-amyloid peptide and growth factors 37. The three-dimensional structure of the dimer reveals its structural organization in the tetrameric native and chymotrypsin alpha 2-macroglobulin complexes. 38. These studies demonstrate that a single mutation in full-length r(alpha)2M is sufficient to block binding to LRP-1. 39. results indicate that secondary proteolysis of alpha2-macroglobulin promotes impaired control of extracellular proteolytic activity, leading to local and distant tissue injuries during severe acute pancreatitis 40. Alpha 2-macroglobulin enhances prothrombin activation and thrombin potential by inhibiting the anticoagulant protein C/protein S system in cord and adult plasma. 41. A2M gene was suggested to be associated with Alzheimer's disease. 42. Alpha2-macroglobulin is a substrate and an endogenous inhibitor for ADAMTS-4 and ADAMTS-5 43. FGF-2 and this protein interact at specific binding sites, involving different FGF-2 sequences. 44. alpha(2)M-derived peptides target the receptor-binding sequence in TGF-beta 45. Differential binding to ldl receptor related protein 46. the inhibition of proteases on the surface of microorganisms by an ancestral alpha2M-like thiol ester protein may generate "arrays" of oligomannose glycans to which MBL or other lectins can bind 47. results did not support the hypothesis that A2M deletion polymorphism is associated with a low A2M concentration in overweight/obese subjects 48. Genetic association of argyrophilic grain disease with polymorphisms in alpha-2 macroglobulin. 49. review of the A2M gene families of mice and humans, the predicted structural relationships between A2M and its pregnancy induced forms and the postulated roles for this gene family in normal pregnancy 50. PAK-2 is activated in 1-LN prostate cancer cells by a proteinase inhibitor, alpha 2-macroglobulin 51. REVIEW: binds and neutralizes alfimeprase, which has direct proteolytic activity against the fibrinogen Aalpha chain 52. The presence of MPO-G/G and A2M-Val/Val genotypes synergistically increased the risk of AD (OR, 25.5; 95% CI, 4.65-139.75). 53. Genetic association of alpha2-macroglobulin polymorphisms with Alzheimer's disease 54. an important involvement of alpha2M in regulation of increased proteolytic activity occurring in multiple sclerosis disease 55. alpha2-M deletion polymorphism is probably not associated with functional deficiencies important in Alzheimer's disease pathology 56. PDGF-BB and TGF-beta1 binding to intact alpha2M is specific, involving a defined region of the alpha2M subunit 57. In this proteins two amino acid polymorphisms (Ile/Val A-->G) have been associated with an increased risk for Alzheimer's disease (AD) and the combination with CTSD-T allele seems to increase this risk. 58. relationship between serum VEGF levels, alpha(2)M levels and the development of OHSS in hyperstimulated subjects undergoing IVF 59. Plasma from patients homozygous for the intronic deletion (DD) showed normal alpha(2)M subunit size, conformation, and proteinase inhibitory activity. Plasma alpha(2)M from two DD patients showed markedly increased TGF-beta1 binding. 60. There is a significant genetic association of the 5 bp deletion and two novel polymorphisms in alpha-2-macroglobulin alpha-2-macroglobulin precursor with AD 61. bone morphogenetic protein 1 is inhibited by native and altered forms of alpha2-macroglobulin 62. alpha(2)M* binding to LRP-1 induces cell proliferation and MAPK activation in the J774 macrophage-derived cell line 63. The risk of symptomatic thromboembolism was significantly increased with elevated alpha2MG levels. 64. alpha2-macroglobulin inhibits human pepsin and gastricsin 65. A2M-D allele played a weak Alzheimer disease protective role, and APOE-E4 and A2M-G alleles might act synergistically in Alzheimer disease risk for mainland Han Chinese. PHENOTYPES ------------------------------------------------------------------------------------------------- Alpha-2-macroglobulin deficiency MIM: 614036, http://www.ncbi.nlm.nih.gov/omim/614036 Alzheimer disease, susceptibility to MIM: 104300, http://www.ncbi.nlm.nih.gov/omim/104300 Emphysema due to alpha-2-macroglobulin deficiency MIM: 103950, http://www.ncbi.nlm.nih.gov/omim/103950 HIV-1 PROTEIN INTERACTION ------------------------------------------------------------------------------------------------- Protein Gene Interaction Pubs ------------------------------------------------------------------------------------------------- Tat tat Binding of HIV-1 Tat to LRP in... PMID: 11100124 retropepsin gag-pol The cleavage site of alpha 2-M... PMID: 7690356,7524416,1724156 INTERACTION ------------------------------------------------------------------------------------------------- Description of Gene Interaction table Product Interactant Other Gene Complex Source Pubs ------------------------------------------------------------------------------------------------- P01023 Q9H013 ADAM19   HPRD PMID: 11162584 P01023 Q9UHI8 ADAMTS1   HPRD PMID: 10373500 P01023 P02760 AMBP   HPRD PMID: 7533162,7519849,1697852 P01023 P08133 ANXA6   HPRD PMID: 15226301 P01023 P02649 APOE   HPRD PMID: 9831625 P01023 Activating transcription factor 7 interacting protein ATF7IP   HPRD PMID: 15231748 P01023 P61769 B2M   HPRD PMID: 10731476 P01023 O00193 C11orf58   HPRD PMID: 16169070 P01023 Q9UNI1 CELA1   HPRD PMID: 6191979,6153632,80233 P01023 P07858 CTSB   HPRD PMID: 2476070 P01023 P14091 CTSE   HPRD PMID: 12631277 P01023 P11021 HSPA5   HPRD PMID: 12194978 P01023 P22301 IL10   HPRD PMID: 10714547 P01023 P01584 IL1B   HPRD PMID: 9714181,2466831 P01023 P20151 KLK2   HPRD PMID: 9428387 P01023 P07288 KLK3   HPRD PMID: 8583572 P01023 P04180 LCAT   HPRD PMID: 11435418 P01023 P41159 LEP   HPRD PMID: 9724081 P01023 Q07954 LRP1   HPRD PMID: 12194978,10652313 P01023 P61626 LYZ   HPRD PMID: 2467766 P01023 P08253 MMP2   HPRD PMID: 9344465 P01023 Q99972 MYOC   HPRD PMID: 16289162 P01023 P01138 NGF   HPRD PMID: 10681572 P01023 P09466 PAEP   HPRD PMID: 11023837 P01023 P04085 PDGFA   HPRD PMID: 10681572 P01023 P01127 PDGFB   HPRD PMID: 10681572 P01023 P04278 SHBG   HPRD PMID: 15862967 P01023 Q15582 TGFBI   HPRD PMID: 10681572 An unspecified isoform of STAT3 binds APRE. Z11711.1 STAT3   BIND PMID: 15950906 Affinity Capture-Western BioGRID:106524 BioGRID:114888 ADAMTS1   BioGRID PMID: 10373500 Affinity Capture-Western BioGRID:106524 BioGRID:106757 AMBP   BioGRID PMID: 7519849,1697852 Two-hybrid BioGRID:106524 BioGRID:106807 ANXA7   BioGRID PMID: 21900206 Affinity Capture-Western; Reconstituted Complex BioGRID:106524 BioGRID:106845 APOE   BioGRID PMID: 9831625 Reconstituted Complex BioGRID:106524 BioGRID:107044 B2M   BioGRID PMID: 10731476 Two-hybrid BioGRID:106524 BioGRID:116144 C11orf58   BioGRID PMID: 21900206 Two-hybrid BioGRID:106524 BioGRID:107433 CDC42   BioGRID PMID: 18624398 Two-hybrid BioGRID:106524 BioGRID:115555 CDK2AP2   BioGRID PMID: 21900206 Two-hybrid BioGRID:106524 BioGRID:107460 CDKN1A   BioGRID PMID: 21900206 Reconstituted Complex BioGRID:106524 BioGRID:107753 CPB2   BioGRID PMID: 8662763 Two-hybrid BioGRID:106524 BioGRID:108937 GEM   BioGRID PMID: 18624398 Two-hybrid BioGRID:106524 BioGRID:109142 GRB2   BioGRID PMID: 18624398 Two-hybrid BioGRID:106524 BioGRID:109268 H2AFX   BioGRID PMID: 21900206 Two-hybrid BioGRID:106524 BioGRID:109406 HMOX2   BioGRID PMID: 21900206 Reconstituted Complex BioGRID:106524 BioGRID:109541 HSPA5   BioGRID PMID: 12194978 Reconstituted Complex BioGRID:106524 BioGRID:109800 IL10   BioGRID PMID: 10714547 Reconstituted Complex BioGRID:106524 BioGRID:109779 IL4   BioGRID PMID: 10714547 Reconstituted Complex BioGRID:106524 BioGRID:117538 KLK13   BioGRID PMID: 14687906 Affinity Capture-Western BioGRID:106524 BioGRID:106850 KLK3   BioGRID PMID: 1702714 Affinity Capture-Western; Reconstituted Complex BioGRID:106524 BioGRID:110123 LCAT   BioGRID PMID: 11435418 Reconstituted Complex BioGRID:106524 BioGRID:110143 LEP   BioGRID PMID: 9724081 Co-crystal Structure BioGRID:106524 BioGRID:110215 LRP1   BioGRID PMID: 10652313 Reconstituted Complex BioGRID:106524 BioGRID:110457 MMP2   BioGRID PMID: 9344465 Reconstituted Complex BioGRID:106524 BioGRID:110869 NGF   BioGRID PMID: 10681572 Two-hybrid BioGRID:106524 BioGRID:116237 NUDT21   BioGRID PMID: 21900206 Co-purification; Reconstituted Complex BioGRID:106524 BioGRID:111084 PAEP   BioGRID PMID: 11023837 Two-hybrid BioGRID:106524 BioGRID:111843 RAP1B   BioGRID PMID: 21900206 Two-hybrid BioGRID:106524 BioGRID:116283 RPP14   BioGRID PMID: 21900206 Two-hybrid BioGRID:106524 BioGRID:116788 SEPT8   BioGRID PMID: 21900206 Two-hybrid BioGRID:106524 BioGRID:112490 SMN1   BioGRID PMID: 21900206 Two-hybrid BioGRID:106524 BioGRID:112908 TGIF1   BioGRID PMID: 21900206 Two-hybrid BioGRID:106524 BioGRID:112938 TK1   BioGRID PMID: 21900206 Two-hybrid BioGRID:106524 BioGRID:114298 TNFRSF14   BioGRID PMID: 21900206 Two-hybrid BioGRID:106524 BioGRID:114374 TSC22D1   BioGRID PMID: 21900206 Two-hybrid BioGRID:106524 BioGRID:113127 TTR   BioGRID PMID: 21900206 Two-hybrid BioGRID:106524 BioGRID:113200 UFD1L   BioGRID PMID: 21900206 GENERAL GENE INFORMATION ------------------------------------------------------------------------------------------------- Marker RH11157 (e-PCR) Links:UniSTS:46849 SGC33440 (e-PCR) Links:UniSTS:54816 G59851 (e-PCR) Links:UniSTS:137000 SGC31674 (e-PCR) Links:UniSTS:40245 D12S1395E (e-PCR) Links:UniSTS:147540 GDB:181517 (e-PCR) Links:UniSTS:155252 RH46356 (e-PCR) Links:UniSTS:75646 D12S1160E (e-PCR) Links:UniSTS:151442 G44356 (e-PCR) Links:UniSTS:95143 RH1601 (e-PCR) Links:UniSTS:25036 RH70338 (e-PCR) Links:UniSTS:31955 PMC311069P4 (e-PCR) Links:UniSTS:272885 Related pseudogene(s) 1 foundReview record(s) in Gene, http://130.14.18.90/gene/?Term=related_functional_gene_2%5Bgroup%5D Genotypes See A2MSNP Geneview Report See A2M SNP Genotype Report See A2M SNP Variation Viewer Report Homology Map Viewer (Mouse, Rat) Pathways from BioSystems Complement and Coagulation Cascades, organism-specific biosystem (from WikiPathways) Complement and coagulation cascades, organism-specific biosystem (from KEGG) Complement and coagulation cascades, conserved biosystem (from KEGG) Formation of Fibrin Clot (Clotting Cascade), organism-specific biosystem (from REACTOME) HDL-mediated lipid transport, organism-specific biosystem (from REACTOME) Hemostasis, organism-specific biosystem (from REACTOME) IL6-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database) Intrinsic Pathway, organism-specific biosystem (from REACTOME) Lipid digestion, mobilization, and transport, organism-specific biosystem (from REACTOME) Lipoprotein metabolism, organism-specific biosystem (from REACTOME) Metabolism, organism-specific biosystem (from REACTOME) Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME) Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME) Platelet degranulation, organism-specific biosystem (from REACTOME) Response to elevated platelet cytosolic Ca2+, organism-specific biosystem (from REACTOME) Rho GTPase cycle, organism-specific biosystem (from REACTOME) Signal Transduction, organism-specific biosystem (from REACTOME) Signaling by Rho GTPases, organism-specific biosystem (from REACTOME) Gene Ontology Provided by GOA (www.ebi.ac.uk/GOA) Function GO ID Evidence ------------------------------------------------------------------------------------------------- enzyme binding GO:0019899 PMID: 11435418 growth factor binding GO:0019838 PMID: 9398211 interleukin-1 binding GO:0019966 PMID: 9714181 interleukin-8 binding GO:0019959 PMID: 10880251 protein binding GO:0005515 PMID: 6698368 serine-type endopeptidase inhibitor acti... GO:0004867 PMID: 12538697 tumor necrosis factor binding GO:0043120 PMID: 9714181 Processs GO ID Evidence ------------------------------------------------------------------------------------------------- blood coagulation GO:0007596 - blood coagulation, intrinsic pathway GO:0007597 - negative regulation of complement activa... GO:0001869 PMID: 12538697 platelet activation GO:0030168 - platelet degranulation GO:0002576 - regulation of small GTPase mediated sign... GO:0051056 - small GTPase mediated signal transductio... GO:0007264 - stem cell differentiation GO:0048863 - Component GO ID Evidence ------------------------------------------------------------------------------------------------- cytosol GO:0005829 - extracellular region GO:0005576 PMID: 14718574 extracellular region GO:0005576 - extracellular space GO:0005615 - platelet alpha granule lumen GO:0031093 - GENERAL PROTEIN INFORMATION ------------------------------------------------------------------------------------------------- Preferred Names alpha-2-macroglobulin Names alpha-2-macroglobulin alpha-2-M C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5 NCBI REFERENCE SEQUENCES (RefSeq) ------------------------------------------------------------------------------------------------- RefSeqs maintained independently of Annotated Genomes These reference sequences exist independently of genome builds. These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products section above. Genomic NG_011717.1 RefSeqGene Range 5000..53254 Download GenBank FASTA Sequence Viewer (Graphics) mRNA and Protein(s) NM_000014.4 → NP_000005.2  REVIEWEDalpha-2-macroglobulin precursor Source sequence(s): BC026246, BC040071, BX504041, BX647329 Consensus CDS: CCDS44827.1 UniProtKB/Swiss-Prot: P01023RelatedENSP00000323929, OTTHUMP00000196829, ENST00000318602, OTTHUMT00000317233 Conserved Domains (7)summary cd02897: Location:958 - 1264 Blast Score:1159 A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnanc... pfam00207: Location:738 - 828 Blast Score:343 A2M; Alpha-2-macroglobulin family pfam01835: Location:129 - 221 Blast Score:264 A2M_N; MG2 domain pfam07677: Location:1376 - 1463 Blast Score:323 A2M_recep; A-macroglobulin receptor pfam07678: Location:1010 - 1266 Blast Score:1002 A2M_comp; A-macroglobulin complement component pfam07703: Location:459 - 607 Blast Score:306 A2M_N_2; Alpha-2-macroglobulin family N-terminal region pfam11974: Location:28 - 110 Blast Score:137 MG1; Alpha-2-macroglobulin MG1 domain RefSeqs of Annotated Genomes: Build 37.3 The following sections contain reference sequences that belong to a specific genome build. This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. Model RNAs and proteins are also reported here. Reference GRCh37.p5 Primary Assembly Genomic NC_000012.11 Reference GRCh37.p5 Primary Assembly Range 9220303..9268557, complement Download GenBank FASTA Sequence Viewer (Graphics) Alternate HuRef Genomic AC_000144.1 Alternate HuRef Range 9000836..9049087, complement Download GenBank FASTA Sequence Viewer (Graphics) RELATED SEQUENCES ------------------------------------------------------------------------------------------------- Nucleotide Protein ------------------------------------------------------------------------------------------------- genomic AC007436.1(30952..79206) None genomic AF349032.1 AAK38109.1 genomic AF349033.1 AAK38110.1 genomic CH471116.2 EAW88590.1 genomic X68728.1 CAA48670.1 genomic X68729.1 None genomic Z11711.1 CAA77774.1 mRNA AB209614.2 BAD92851.1 mRNA AK307832.1 None mRNA AK312482.1 None mRNA AY591530.1 AAT02228.1 mRNA BC026246.1 AAH26246.1 mRNA BC040071.1 AAH40071.1 mRNA BX504041.1 None mRNA BX647329.1 None mRNA CR749334.1 CAH18188.1 mRNA M11313.1 AAA51551.1 mRNA M36501.1 AAA51552.1 Protein Accession Links ------------------------------------------------------------------------------------------------- P01023.3 GenPept UniProtKB/Swiss-Prot:P01023 Q9BQ22 GenPept UniProtKB/TrEMBL:Q9BQ22 ADDITIONAL LINKS ------------------------------------------------------------------------------------------------- MIM 103950 PharmGKB PA24357 UCSC UCSC UniGene Hs.212838 GENE LINKOUT ------------------------------------------------------------------------------------------------- The following LinkOut(www.ncbi.nlm.nih.gov/projects/linkout/index.html) resources are supplied by external providers. These providers are responsible for maintaining the links. Chemical Information (Free resource) (free) Interologous Interaction Database Medical (Free resource) (free) Pancreatic Expression Database (Free resource) (free) Breast Cancer TissueBank Bioinformatics Portal Molecular Biology Databases (Free resource) (free) CutDB, Proteolytic Event Database (part of Proteolysis MAP (PMAP), proteolysis reasoning environment) (Free resource) (free) PhosphoSitePlus comprehensive information related to post-translational modifications (Free resource) (free) pfSNP (Free resource) (free) OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs (Free resource) (free) NextBio (Free resource) (free) Pathway Interaction Database KOMP Repository (Free resource) (free) Kyoto Encyclopedia of Genes and Genomes hsa:2Complement and coagulation cascades (Free resource) (free) XTractor Manually annotated facts for A2MG (Free resource) (free) InnateDB Ingenuity Pathways Analysis (Free resource) (free) iHOP - Information Hyperlinked over Proteins (Free resource) (free) HuRef Browser HuRef Genome Annotation (Free resource) (Free registration required) (free) Human Gene Mutation Database (Free resource) (free) BioGPS (Free resource) (Order form) (Free registration required) (free) GenScript (Free resource) (free) GeneNetwork Records for gene expression in Human GeneGo (Free resource) (free) GenAge Database of Aging Related Genes (Free resource) (free) Genetic Association Database (Free resource) (free) FuncBase Gene Function Prediction Viewer Predicted Gene Functions (Free resource) (free) Domain Mapping of Disease Mutations A2M (Free resource) (free) BioLink: Biological knowledge connections (Free resource) (free) CREB Target Gene Database (Free resource) (free) The Comparative Toxicogenomics Database (Free resource) (free) iRefWeb - iRefIndex release 9.0 - Consolidated Interactome Research Materials (Order form) NITE Biological Resource Center Human cDNA clones used in NEDO Project / AK312482Human cDNA clones used in NEDO Project / AK307832 (Order form) Kazusa DNA Research Institute (Order form) GeneCopoeia Inc. Order shRNA clonesOrder promoter cloneOrder full-length ORF cloneOrder miRNA target clones (Order form) antibodies-online alpha-2-Macroglobulin (A2M) ELISA kitsalpha-2-Macroglobulin (A2M) proteinsanti-alpha-2-Macroglobulin (A2M) antibodies (Order form) TaqMan probe and primer sets (Assays) and RNAi products from Life Technologies Silencer Select siRNATaqMan® Gene Expression AssaysGenotyping Assays Tools (Free resource) (free) GeneMANIA