ENTRY b0002 CDS T00007 SYMBOL thrA NAME (RefSeq) fused aspartate kinase/homoserine dehydrogenase 1 ORTHOLOGY K12524 bifunctional aspartokinase / homoserine dehydrogenase 1 [EC:2.7.2.4 1.1.1.3] ORGANISM eco Escherichia coli K-12 MG1655 PATHWAY eco00260 Glycine, serine and threonine metabolism eco00261 Monobactam biosynthesis eco00270 Cysteine and methionine metabolism eco00300 Lysine biosynthesis eco01100 Metabolic pathways eco01110 Biosynthesis of secondary metabolites eco01120 Microbial metabolism in diverse environments eco01230 Biosynthesis of amino acids MODULE eco_M00016 Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine eco_M00017 Methionine biosynthesis, aspartate => homoserine => methionine eco_M00018 Threonine biosynthesis, aspartate => homoserine => threonine BRITE KEGG Orthology (KO) [BR:eco00001] 09100 Metabolism 09105 Amino acid metabolism 00260 Glycine, serine and threonine metabolism b0002 (thrA) 00270 Cysteine and methionine metabolism b0002 (thrA) 00300 Lysine biosynthesis b0002 (thrA) 09110 Biosynthesis of other secondary metabolites 00261 Monobactam biosynthesis b0002 (thrA) Enzymes [BR:eco01000] 1. Oxidoreductases 1.1 Acting on the CH-OH group of donors 1.1.1 With NAD+ or NADP+ as acceptor 1.1.1.3 homoserine dehydrogenase b0002 (thrA) 2. Transferases 2.7 Transferring phosphorus-containing groups 2.7.2 Phosphotransferases with a carboxy group as acceptor 2.7.2.4 aspartate kinase b0002 (thrA) POSITION 337..2799 MOTIF Pfam: Homoserine_dh AA_kinase NAD_binding_3 ACT_7 ACT DUF6247 DBLINKS NCBI-GeneID: 945803 NCBI-ProteinID: NP_414543 Pasteur: thrA RegulonDB: ECK120000987 ECOCYC: EG10998 ASAP: ABE-0000008 UniProt: P00561 STRUCTURE PDB AASEQ 820 MRVLKFGGTSVANAERFLRVADILESNARQGQVATVLSAPAKITNHLVAMIEKTISGQDA LPNISDAERIFAELLTGLAAAQPGFPLAQLKTFVDQEFAQIKHVLHGISLLGQCPDSINA ALICRGEKMSIAIMAGVLEARGHNVTVIDPVEKLLAVGHYLESTVDIAESTRRIAASRIP ADHMVLMAGFTAGNEKGELVVLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYTCDPRQV PDARLLKSMSYQEAMELSYFGAKVLHPRTITPIAQFQIPCLIKNTGNPQAPGTLIGASRD EDELPVKGISNLNNMAMFSVSGPGMKGMVGMAARVFAAMSRARISVVLITQSSSEYSISF CVPQSDCVRAERAMQEEFYLELKEGLLEPLAVTERLAIISVVGDGMRTLRGISAKFFAAL ARANINIVAIAQGSSERSISVVVNNDDATTGVRVTHQMLFNTDQVIEVFVIGVGGVGGAL LEQLKRQQSWLKNKHIDLRVCGVANSKALLTNVHGLNLENWQEELAQAKEPFNLGRLIRL VKEYHLLNPVIVDCTSSQAVADQYADFLREGFHVVTPNKKANTSSMDYYHQLRYAAEKSR RKFLYDTNVGAGLPVIENLQNLLNAGDELMKFSGILSGSLSYIFGKLDEGMSFSEATTLA REMGYTEPDPRDDLSGMDVARKLLILARETGRELELADIEIEPVLPAEFNAEGDVAAFMA NLSQLDDLFAARVAKARDEGKVLRYVGNIDEDGVCRVKIAEVDGNDPLFKVKNGENALAF YSHYYQPLPLVLRGYGAGNDVTAAGVFADLLRTLSWKLGV NTSEQ 2463 atgcgagtgttgaagttcggcggtacatcagtggcaaatgcagaacgttttctgcgtgtt gccgatattctggaaagcaatgccaggcaggggcaggtggccaccgtcctctctgccccc gccaaaatcaccaaccacctggtggcgatgattgaaaaaaccattagcggccaggatgct ttacccaatatcagcgatgccgaacgtatttttgccgaacttttgacgggactcgccgcc gcccagccggggttcccgctggcgcaattgaaaactttcgtcgatcaggaatttgcccaa ataaaacatgtcctgcatggcattagtttgttggggcagtgcccggatagcatcaacgct gcgctgatttgccgtggcgagaaaatgtcgatcgccattatggccggcgtattagaagcg cgcggtcacaacgttactgttatcgatccggtcgaaaaactgctggcagtggggcattac ctcgaatctaccgtcgatattgctgagtccacccgccgtattgcggcaagccgcattccg gctgatcacatggtgctgatggcaggtttcaccgccggtaatgaaaaaggcgaactggtg gtgcttggacgcaacggttccgactactctgctgcggtgctggctgcctgtttacgcgcc gattgttgcgagatttggacggacgttgacggggtctatacctgcgacccgcgtcaggtg cccgatgcgaggttgttgaagtcgatgtcctaccaggaagcgatggagctttcctacttc ggcgctaaagttcttcacccccgcaccattacccccatcgcccagttccagatcccttgc ctgattaaaaataccggaaatcctcaagcaccaggtacgctcattggtgccagccgtgat gaagacgaattaccggtcaagggcatttccaatctgaataacatggcaatgttcagcgtt tctggtccggggatgaaagggatggtcggcatggcggcgcgcgtctttgcagcgatgtca cgcgcccgtatttccgtggtgctgattacgcaatcatcttccgaatacagcatcagtttc tgcgttccacaaagcgactgtgtgcgagctgaacgggcaatgcaggaagagttctacctg gaactgaaagaaggcttactggagccgctggcagtgacggaacggctggccattatctcg gtggtaggtgatggtatgcgcaccttgcgtgggatctcggcgaaattctttgccgcactg gcccgcgccaatatcaacattgtcgccattgctcagggatcttctgaacgctcaatctct gtcgtggtaaataacgatgatgcgaccactggcgtgcgcgttactcatcagatgctgttc aataccgatcaggttatcgaagtgtttgtgattggcgtcggtggcgttggcggtgcgctg ctggagcaactgaagcgtcagcaaagctggctgaagaataaacatatcgacttacgtgtc tgcggtgttgccaactcgaaggctctgctcaccaatgtacatggccttaatctggaaaac tggcaggaagaactggcgcaagccaaagagccgtttaatctcgggcgcttaattcgcctc gtgaaagaatatcatctgctgaacccggtcattgttgactgcacttccagccaggcagtg gcggatcaatatgccgacttcctgcgcgaaggtttccacgttgtcacgccgaacaaaaag gccaacacctcgtcgatggattactaccatcagttgcgttatgcggcggaaaaatcgcgg cgtaaattcctctatgacaccaacgttggggctggattaccggttattgagaacctgcaa aatctgctcaatgcaggtgatgaattgatgaagttctccggcattctttctggttcgctt tcttatatcttcggcaagttagacgaaggcatgagtttctccgaggcgaccacgctggcg cgggaaatgggttataccgaaccggacccgcgagatgatctttctggtatggatgtggcg cgtaaactattgattctcgctcgtgaaacgggacgtgaactggagctggcggatattgaa attgaacctgtgctgcccgcagagtttaacgccgagggtgatgttgccgcttttatggcg aatctgtcacaactcgacgatctctttgccgcgcgcgtggcgaaggcccgtgatgaagga aaagttttgcgctatgttggcaatattgatgaagatggcgtctgccgcgtgaagattgcc gaagtggatggtaatgatccgctgttcaaagtgaaaaatggcgaaaacgccctggccttc tatagccactattatcagccgctgccgttggtactgcgcggatatggtgcgggcaatgac gttacagctgccggtgtctttgctgatctgctacgtaccctctcatggaagttaggagtc tga ///