ENTRY       M00009            Pathway   Module
NAME        Citrate cycle (TCA cycle, Krebs cycle)
DEFINITION  (K01647,K05942,K01659) (K01681,K27802,K01682) (K00031,K00030) ((K00164+K00658,K01616)+K00382,K00174+K00175-K00177-K00176) (K01902+K01903,K01899+K01900,K18118) (K00234+K00235+K00236+(K00237,K25801),K00239+K00240+K00241-(K00242,K18859,K18860),K00244+K00245+K00246-K00247) (K01676,K01679,K01677+K01678) (K00026,K00025,K00024,K00116)
ORTHOLOGY   K01647  citrate synthase [EC:2.3.3.1] [RN:R00351]
            K05942  citrate (Re)-synthase [EC:2.3.3.3] [RN:R00351]
            K01659  2-methylcitrate synthase [EC:2.3.3.5] [RN:R00351]
            K01681,K27802,K01682  aconitate hydratase [EC:4.2.1.3] [RN:R01325 R01900 R01324]
            K00031,K00030  isocitrate dehydrogenase [EC:1.1.1.42 1.1.1.41] [RN:R01899 R00268 R00267 R00709]
            K00164,K01616,K00658,K00382  2-oxoglutarate dehydrogenase complex [EC:1.2.4.2 2.3.1.61 1.8.1.4] [RN:R00621 R03316 R01700 R02570 R07618]
            K00174  2-oxoglutarate/2-oxoacid ferredoxin oxidoreductase subunit alpha [EC:1.2.7.3 1.2.7.11] [RN:R01197]
            K00175  2-oxoglutarate/2-oxoacid ferredoxin oxidoreductase subunit beta [EC:1.2.7.3 1.2.7.11] [RN:R01197]
            K00177  2-oxoglutarate ferredoxin oxidoreductase subunit gamma [EC:1.2.7.3] [RN:R01197]
            K00176  2-oxoglutarate ferredoxin oxidoreductase subunit delta [EC:1.2.7.3] [RN:R01197]
            K01902,K01903  succinyl-CoA synthetase [EC:6.2.1.5] [RN:R00405]
            K01899,K01900  succinyl-CoA synthetase [EC:6.2.1.4 6.2.1.5] [RN:R00405 R00432 R00727]
            K18118  succinyl-CoA:acetate CoA-transferase [EC:2.8.3.18] [RN:R10343]
            K00234,K00235,K00236,K00237,K25801  succinate dehydrogenase [EC:1.3.5.1] [RN:R02164]
            K00239,K00240,K00241,K00242,K18859,K18860 succinate dehydrogenase [EC:1.3.5.1] [RN:R02164]
            K00244,K00245,K00246,K00247 succinate dehydrogenase [EC:1.3.5.1] [RN:R02164]
            K01676,K01679,K01677,K01678  fumarate hydratase [EC:4.2.1.2] [RN:R01082]
            K00026,K00025,K00024  malate dehydrogenase [EC:1.1.1.37] [RN:R00342]
            K00116  malate dehydrogenase (quinone) [EC:1.1.5.4] [RN:R00361]
CLASS       Pathway modules; Carbohydrate metabolism; Central carbohydrate metabolism
PATHWAY     map00020  Citrate cycle (TCA cycle)
            map01200  Carbon metabolism
            map01100  Metabolic pathways
REACTION    R00351  C00024 + C00036 -> C00158
            R01325+R01900,R01324  C00158 -> C00311
            R01899+R00268,R00267,R00709  C00311 -> C00026
            R00621+R03316,R01700  C00026 + C15972 -> C16254
            R02570  C16254 -> C00091 + C15973
            R07618  C15973 -> C15972
            R01197  C00026 -> C00091
            R00405,R00432,R00727,R10343  C00091 -> C00042
            R02164  C00042 -> C00122
            R01082  C00122 -> C00149
            R00342,R00361  C00149 -> C00036
COMPOUND    C00024  Acetyl-CoA
            C00036  Oxaloacetate
            C00158  Citrate
            C00311  Isocitrate
            C00026  2-Oxoglutarate
            C15972  Enzyme N6-(lipoyl)lysine
            C16254  [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine
            C00091  Succinyl-CoA
            C15973  Enzyme N6-(dihydrolipoyl)lysine
            C00042  Succinate
            C00122  Fumarate
            C00149  (S)-Malate
///