PMID- 10021291
OWN - NLM
STAT- MEDLINE
DCOM- 19990311
LR  - 20061115
IS  - 0090-8258 (Print)
IS  - 0090-8258 (Linking)
VI  - 72
IP  - 2
DP  - 1999 Feb
TI  - Adipose tissue distribution in postmenopausal women with adenomatous hyperplasia 
      of the endometrium.
PG  - 138-42
AB  - OBJECTIVE: To investigate body fat distribution in postmenopausal women with 
      adenomatous and atypical hyperplasia of the endometrium. METHODS: A prospective 
      population-based case control study was performed in a health care county in 
      Sweden. General obesity, as reflected by body mass index (BMI), and adipose 
      tissue distribution, expressed as waist to hip circumference ratio (WHR), were 
      evaluated in a cohort of 367 postmenopausal women who underwent dilatation and 
      curettage because of uterine bleeding. The study group consisted of 29 women with 
      adenomatous or atypical hyperplasia of the endometrium. The controls consisted of 
      49 age-matched postmenopausal women randomly selected from the computerized 
      population register of the same region. RESULTS: The frequency of endometrial 
      adenomatous and atypical hyperplasia in postmenopausal women with bleeding was 
      7.2%. In the total population of postmenopausal women the incidence of these 
      endometrial lesions was 44 per 100,000 per year. Body weight (P = 0.039), BMI (P 
      = 0.007), and WHR (P = 0.022) were higher in postmenopausal women with 
      endometrial adenomatous and atypical hyperplasia than in controls. In 
      multivariate analysis only BMI remained statistically associated with adenomatous 
      hyperplasia (P = 0.012). CONCLUSIONS: General obesity, but neither upper nor 
      lower body fat distribution, was characteristic of postmenopausal women with 
      adenomatous and atypical hyperplasia of the endometrium. Overall obesity is a 
      risk factor for these endometrial precancerous lesions, as it is also claimed to 
      be for endometrial cancer.
CI  - Copyright 1999 Academic Press.
FAU - Gredmark, T
AU  - Gredmark T
AD  - Department of Obstetrics and Gynecology, Central Hospital, Skovde, Sweden.
FAU - Kvint, S
AU  - Kvint S
FAU - Havel, G
AU  - Havel G
FAU - Mattsson, L A
AU  - Mattsson LA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Gynecol Oncol
JT  - Gynecologic oncology
JID - 0365304
SB  - IM
MH  - Adipose Tissue/*pathology
MH  - Adult
MH  - Age Distribution
MH  - Aged
MH  - Aged, 80 and over
MH  - Anthropometry
MH  - Body Composition
MH  - Body Mass Index
MH  - Case-Control Studies
MH  - Cohort Studies
MH  - Endometrial Hyperplasia/*pathology
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Obesity/*pathology
MH  - Postmenopause
MH  - Prospective Studies
MH  - Risk Factors
EDAT- 1999/02/18 00:00
MHDA- 1999/02/18 00:01
CRDT- 1999/02/18 00:00
PHST- 1999/02/18 00:00 [pubmed]
PHST- 1999/02/18 00:01 [medline]
PHST- 1999/02/18 00:00 [entrez]
AID - S0090-8258(98)95252-0 [pii]
AID - 10.1006/gyno.1998.5252 [doi]
PST - ppublish
SO  - Gynecol Oncol. 1999 Feb;72(2):138-42. doi: 10.1006/gyno.1998.5252.