PMID- 10022582
OWN - NLM
STAT- MEDLINE
DCOM- 19990507
LR  - 20191102
IS  - 0022-3034 (Print)
IS  - 0022-3034 (Linking)
VI  - 38
IP  - 3
DP  - 1999 Feb 15
TI  - Developing vestibular ganglion neurons switch trophic sensitivity from BDNF to 
      GDNF after target innervation.
PG  - 414-27
AB  - Recent evidence showing a distinctive cell loss in vestibular and cochlear 
      ganglia of brain-derived neurotrophic factor (BDNF) versus neurotrophin-3 (NT-3) 
      null mutant mice demonstrates that these neurotrophins play a critical role in 
      inner ear development. In this study, biological functions of BDNF and NT-3 in 
      the chick vestibular and cochlear ganglion development was assessed in vitro and 
      compared to those of other neurotrophic factors. The embryonic day (E)8-12 
      vestibular ganglion neurons showed an extensive outgrowth in response to BDNF 
      with less outgrowth to NT-3. In contrast, NT-3 had stronger neurotrophic effects 
      on the E12 cochlear ganglion neurons compared to BDNF. These results support 
      previous evidence that neurotrophins play important roles in the vestibular and 
      cochlear ganglion neuron development. However, the responsiveness to the 
      neurotrophins declined and became undetectable by E16. Unexpectedly, glial cell 
      line-derived neurotrophic factor (GDNF) promoted neurite outgrowth from 
      vestibular ganglia at E12-16, later than the stages at which BDNF had 
      neurotrophic effects. The time of switching sensitivity of the vestibular 
      ganglion neurons from BDNF to GDNF correlated with the time of completion of 
      synaptogenesis on their peripheral and central targets. Furthermore, a factor 
      released from E12 inner ears exerted neurotrophic effects on late-stage 
      vestibular ganglion neurons that were not responsive to the E4 otocyst-derived 
      factor. These results raise the possibility that the vestibular ganglion neurons 
      become responsive to GDNF upon target innervation and that the changes in 
      sensitivity are regulated by changes in available factors released from their 
      peripheral targets, the inner ear epithelia.
FAU - Hashino, E
AU  - Hashino E
AD  - Department of Anatomy and Cell Biology, State University of New York at Buffalo, 
      14214, USA.
FAU - Dolnick, R Y
AU  - Dolnick RY
FAU - Cohan, C S
AU  - Cohan CS
LA  - eng
GR  - R01 DC01785/DC/NIDCD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Neurobiol
JT  - Journal of neurobiology
JID - 0213640
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Culture Media, Conditioned)
RN  - 0 (Glial Cell Line-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Neurotrophin 3)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*physiology
MH  - Chick Embryo
MH  - Cochlear Nucleus/cytology/embryology
MH  - Culture Media, Conditioned
MH  - Glial Cell Line-Derived Neurotrophic Factor
MH  - Nerve Fibers/ultrastructure
MH  - Nerve Growth Factors/*physiology
MH  - Nerve Tissue Proteins/*physiology
MH  - Neurons/*physiology
MH  - Neurotrophin 3
MH  - Organ Culture Techniques
MH  - Vestibular Nuclei/*cytology/*embryology
EDAT- 1999/02/18 03:02
MHDA- 2000/06/20 09:00
CRDT- 1999/02/18 03:02
PHST- 1999/02/18 03:02 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1999/02/18 03:02 [entrez]
AID - 10.1002/(SICI)1097-4695(19990215)38:3<414::AID-NEU9>3.0.CO;2-Y [pii]
AID - 10.1002/(sici)1097-4695(19990215)38:3<414::aid-neu9>3.0.co;2-y [doi]
PST - ppublish
SO  - J Neurobiol. 1999 Feb 15;38(3):414-27. doi: 
      10.1002/(sici)1097-4695(19990215)38:3<414::aid-neu9>3.0.co;2-y.