PMID- 10022958
OWN - NLM
STAT- MEDLINE
DCOM- 19990413
LR  - 20190720
IS  - 0302-766X (Print)
IS  - 0302-766X (Linking)
VI  - 295
IP  - 3
DP  - 1999 Mar
TI  - Making and breaking the innervation of the ear: neurotrophic support during ear 
      development and its clinical implications.
PG  - 369-82
AB  - Analyses of single and double mutants of members of the neurotrophin family and 
      their receptors are reviewed. These data demonstrate that the two neurotrophins, 
      brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT-3), and their 
      high-affinity receptors trkB and trkC, are the sole support for the developing 
      afferent innervation of the ear. Neurotrophins are first expressed in the otocyst 
      around the time afferent sensory neurons become postmitotic. They are crucial for 
      the survival of certain topologically distinct populations of sensory neurons. 
      BDNF supports all sensory neurons to the semicircular canals, most sensory 
      neurons to the saccule and utricle, and many sensory neurons to the apex and 
      middle turn of the cochlea. In contrast, NT-3 supports few sensory neurons to the 
      utricle and saccule, all sensory neurons to the basal turn of the cochlea and 
      most sensory neurons to the middle and apical turn. Some topologically restricted 
      effects reflect the pattern of neurotrophin distribution as revealed by in situ 
      hybridization (e.g., loss of all innervation to the semicircular canal sensory 
      epithelia in BDNF or trkB mutants). However, other topologically restricted 
      effects cannot be explained on the basis of current knowledge of neurotrophin or 
      neurotrophin receptor distribution. Data on mutants also support the notion that 
      BDNF may play a role in neonatal plastic reorganization of the pattern of 
      innervation in the ear and possibly the brainstem. In contrast, data obtained 
      thus far on the ability of neurotrophins to rescue adult sensory neuron after 
      insults to cochlear hair cells are less compelling. The ear is a model system to 
      test the interactions of the two neurotrophins, BDNF and NT-3, with their two 
      high-affinity receptors, trkB and trkC.
FAU - Fritzsch, B
AU  - Fritzsch B
AD  - Department of Biomedical Sciences, Creighton University, Omaha, 2400 California 
      Plaza, NE 68178, USA. fritzsch@creighton.edu
FAU - Pirvola, U
AU  - Pirvola U
FAU - Ylikoski, J
AU  - Ylikoski J
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Germany
TA  - Cell Tissue Res
JT  - Cell and tissue research
JID - 0417625
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (GDNF protein, human)
RN  - 0 (Glial Cell Line-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Neurotrophin 3)
SB  - IM
MH  - Adult
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*physiology
MH  - Ear/embryology/*innervation
MH  - Ganglia/physiology
MH  - Glial Cell Line-Derived Neurotrophic Factor
MH  - Hair Cells, Auditory
MH  - Humans
MH  - Nerve Growth Factors/*physiology
MH  - Nerve Tissue Proteins/physiology
MH  - Neuronal Plasticity
MH  - Neurons, Afferent/physiology
MH  - Neurotrophin 3
RF  - 97
EDAT- 1999/02/18 00:00
MHDA- 1999/02/18 00:01
CRDT- 1999/02/18 00:00
PHST- 1999/02/18 00:00 [pubmed]
PHST- 1999/02/18 00:01 [medline]
PHST- 1999/02/18 00:00 [entrez]
AID - 10.1007/s004410051244 [doi]
PST - ppublish
SO  - Cell Tissue Res. 1999 Mar;295(3):369-82. doi: 10.1007/s004410051244.