PMID- 10023500
OWN - NLM
STAT- MEDLINE
DCOM- 19990507
LR  - 20221207
IS  - 0006-3223 (Print)
IS  - 0006-3223 (Linking)
VI  - 45
IP  - 3
DP  - 1999 Feb 1
TI  - Combination of inositol and serotonin reuptake inhibitors in the treatment of 
      depression.
PG  - 270-3
AB  - BACKGROUND: Inositol has been reported to be an effective treatment in 
      depression, and we hypothesized that inositol addition might enhance or speed up 
      response to serotonin selective reuptake inhibitors (SSRI). METHODS: Twenty-seven 
      depressed patients completed a double-blind controlled 4-week trial of SSRI plus 
      placebo or SSRI plus inositol. Hamilton Depression Rating Scale was used as an 
      assessment tool at baseline, and 1, 2, 3, and 4 weeks. RESULTS: No significant 
      difference was found between the two treatment groups. CONCLUSIONS: Previous 
      studies combining different effective antidepressant therapies similarly found no 
      evidence for additive effects [e.g., monoamine oxidase inhibitors (MAOI) plus 
      tricyclic antidepressants (TCA), TCA plus lithium]. By contrast, augmentation by 
      lithium or MAOI after a failed course of antidepressant treatment is effective 
      and should be studied with inositol.
FAU - Levine, J
AU  - Levine J
AD  - Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion 
      University of the Negev, Beersheva, Israel.
FAU - Mishori, A
AU  - Mishori A
FAU - Susnosky, M
AU  - Susnosky M
FAU - Martin, M
AU  - Martin M
FAU - Belmaker, R H
AU  - Belmaker RH
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Biol Psychiatry
JT  - Biological psychiatry
JID - 0213264
RN  - 0 (Serotonin Uptake Inhibitors)
RN  - 4L6452S749 (Inositol)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Analysis of Variance
MH  - Depressive Disorder/*drug therapy
MH  - Double-Blind Method
MH  - Drug Therapy, Combination
MH  - Female
MH  - Humans
MH  - Inositol/*therapeutic use
MH  - Male
MH  - Middle Aged
MH  - Selective Serotonin Reuptake Inhibitors/*therapeutic use
MH  - Treatment Outcome
EDAT- 1999/02/19 00:00
MHDA- 1999/02/19 00:01
CRDT- 1999/02/19 00:00
PHST- 1999/02/19 00:00 [pubmed]
PHST- 1999/02/19 00:01 [medline]
PHST- 1999/02/19 00:00 [entrez]
AID - S0006-3223(98)00145-0 [pii]
AID - 10.1016/s0006-3223(98)00145-0 [doi]
PST - ppublish
SO  - Biol Psychiatry. 1999 Feb 1;45(3):270-3. doi: 10.1016/s0006-3223(98)00145-0.