PMID- 10025125
OWN - NLM
STAT- MEDLINE
DCOM- 19990407
LR  - 20190826
IS  - 0030-6622 (Print)
IS  - 0030-6622 (Linking)
VI  - 101
IP  - 12
DP  - 1998 Dec
TI  - [Studies on deletion of 1p36 in oral squamous cell carcinoma].
PG  - 1430-5
AB  - The deletion of region 36 in the short arm of chromosome 1 (1p36) was 
      investigated in 18 patients with oral squamous cell carcinoma by means of the 
      double-target fluorescence in situ hybridization (FISH) method. 1p36 has been 
      suggested to harbor a putative tumor suppressor gene, and thought to carry 
      several genes such as p58, FRAP and TNF-R II. The deletion of 1p36 may play a 
      part in cell regulation, apotosis, promotion and progression of carcinoma cells. 
      The double-target FISH was completed by the use of a biotin-labeled chromosome 1 
      centromeric repetitive probe and a digoxigenin-labeled 1p36 probe in biopsied 
      specimens obtained from these patients before the treatment. The ploidy pattern 
      of the nuclear DNA of these specimens was also examined by flow cytometry. The 
      deletion of 1p36 was observed in 3 patients with poor prognosis showing 
      aneuploidy in their nuclear DNA. These results may indicate that the deletion of 
      1p36 can be a reliable factor in the poor prognosis of patients with oral 
      squamous cell carcinoma.
FAU - Kimura, T
AU  - Kimura T
AD  - Department of Otolaryngology, Kyoto Prefectual University of Medicine.
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Nihon Jibiinkoka Gakkai Kaiho
JT  - Nihon Jibiinkoka Gakkai kaiho
JID - 7505728
RN  - 0 (DNA, Neoplasm)
SB  - IM
MH  - Carcinoma, Squamous Cell/*genetics/pathology
MH  - *Chromosomes, Human, Pair 1
MH  - DNA, Neoplasm/genetics
MH  - *Gene Deletion
MH  - Genes, Tumor Suppressor
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Mouth Neoplasms/*genetics/pathology
MH  - Ploidies
MH  - Prognosis
EDAT- 1999/02/20 00:00
MHDA- 1999/02/20 00:01
CRDT- 1999/02/20 00:00
PHST- 1999/02/20 00:00 [pubmed]
PHST- 1999/02/20 00:01 [medline]
PHST- 1999/02/20 00:00 [entrez]
AID - 10.3950/jibiinkoka.101.12_1430 [doi]
PST - ppublish
SO  - Nihon Jibiinkoka Gakkai Kaiho. 1998 Dec;101(12):1430-5. doi: 
      10.3950/jibiinkoka.101.12_1430.