PMID- 10025735
OWN - NLM
STAT- MEDLINE
DCOM- 19990413
LR  - 20231014
IS  - 0887-8013 (Print)
IS  - 1098-2825 (Electronic)
IS  - 0887-8013 (Linking)
VI  - 13
IP  - 1
DP  - 1999
TI  - Evaluating response to nutritional therapy using the branched-chain amino 
      acid/tyrosine ratio in patients with chronic liver disease.
PG  - 31-4
AB  - The branched-chain amino acid (BCAA)/tyrosine (Tyr) ratio (BTR) recently has been 
      reported to be a good indicator of the severity of hepatic parenchymal injury in 
      patients with chronic liver disease. In the present study, sequential changes of 
      BTR after BCAA administration were determined in patients with chronic liver 
      disease to evaluate the value of BTR as a marker of the clinical response to 
      nutritional therapy in these patients. This study comprised 75 patients with 
      chronic hepatitis and 96 with liver cirrhosis. BTR was significantly decreased in 
      patients with cirrhosis and hepatitis compared with healthy subjects. BTR was 
      significantly correlated with the Child-Pugh score and with other liver function 
      tests. BCAA increased significantly 2 hr after BCAA administration and decreased 
      gradually thereafter. Tyr significantly decreased 4 hr after BCAA administration. 
      BTR significantly increased 2 and 4 hr after BCAA therapy. The increase in BTR 3 
      hr after BCAA administration was low in patients with decreased basal BTR. The 
      results of this study showed that BTR is a good index of the hepatic parenchymal 
      damage and that it may be a useful marker for monitoring response to nutritional 
      therapy in patients with chronic liver disease.
FAU - Kawamura-Yasui, N
AU  - Kawamura-Yasui N
AD  - Third Department of Internal Medicine, Mie University School of Medicine, Tsu, 
      Japan. naika@clin.medic.mie-u.ac.jp
FAU - Kaito, M
AU  - Kaito M
FAU - Nakagawa, N
AU  - Nakagawa N
FAU - Fujita, N
AU  - Fujita N
FAU - Ikoma, J
AU  - Ikoma J
FAU - Gabazza, E C
AU  - Gabazza EC
FAU - Watanabe, S
AU  - Watanabe S
FAU - Adachi, Y
AU  - Adachi Y
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Lab Anal
JT  - Journal of clinical laboratory analysis
JID - 8801384
RN  - 0 (Amino Acids, Branched-Chain)
RN  - 0 (Dietary Proteins)
RN  - 0 (Serum Albumin)
RN  - 42HK56048U (Tyrosine)
RN  - 9004-61-9 (Hyaluronic Acid)
RN  - EC 3.1.1.8 (Cholinesterases)
RN  - RFM9X3LJ49 (Bilirubin)
SB  - IM
MH  - Amino Acids, Branched-Chain/administration & dosage/*blood
MH  - Bilirubin/blood
MH  - Cholinesterases/blood
MH  - Chronic Disease
MH  - Dietary Proteins/administration & dosage
MH  - Female
MH  - Hepatitis, Chronic/blood/diet therapy
MH  - Humans
MH  - Hyaluronic Acid/blood
MH  - Kinetics
MH  - Liver Cirrhosis/blood/diet therapy
MH  - Liver Diseases/blood/*diet therapy
MH  - Male
MH  - Middle Aged
MH  - Platelet Count
MH  - Serum Albumin/analysis
MH  - Tyrosine/*blood
PMC - PMC6808106
EDAT- 1999/02/20 03:12
MHDA- 2000/06/20 09:00
PMCR- 1999/01/29
CRDT- 1999/02/20 03:12
PHST- 1999/02/20 03:12 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1999/02/20 03:12 [entrez]
PHST- 1999/01/29 00:00 [pmc-release]
AID - 10.1002/(SICI)1098-2825(1999)13:1<31::AID-JCLA6>3.0.CO;2-Y [pii]
AID - JCLA6 [pii]
AID - 10.1002/(SICI)1098-2825(1999)13:1&#x0003c;31::AID-JCLA6&#x0003e;3.0.CO;2-Y [doi]
PST - ppublish
SO  - J Clin Lab Anal. 1999;13(1):31-4. doi: 
      10.1002/(SICI)1098-2825(1999)13:1&#x0003c;31::AID-JCLA6&#x0003e;3.0.CO;2-Y.