PMID- 10026353
OWN - NLM
STAT- MEDLINE
DCOM- 19990603
LR  - 20190503
IS  - 1355-6037 (Print)
IS  - 1468-201X (Electronic)
IS  - 1355-6037 (Linking)
VI  - 81
IP  - 3
DP  - 1999 Mar
TI  - Endogenous plasma endothelin concentrations and coronary circulation in patients 
      with mild dilated cardiomyopathy.
PG  - 278-84
AB  - OBJECTIVE: To determine whether increased plasma concentrations of endothelin-1 
      (ET-1) and big endothelin (BET) play a role in the regulation of coronary 
      circulation in patients with idiopathic dilated cardiomyopathy (IDCM). SETTING: 
      Tertiary referral centre for cardiac diseases. PATIENTS: Fourteen patients (eight 
      male/six female; mean (SD) age 59 (9) years) with IDCM (ejection fraction 36 
      (9)%) and five normotensive subjects (two male/three female; age 52 (7) years) 
      serving as controls were studied. METHODS: Functional status was classified 
      according to New York Heart Association (NYHA) class. Endogenous ET-1 and BET 
      plasma concentrations from the aorta and the coronary sinus were determined by 
      radioimmunoassay. Coronary blood flow, using the inert chromatographic argon 
      method, myocardial oxygen consumption, and coronary sinus oxygen content under 
      basal conditions were determined. RESULTS: In the aorta, mean (SD) concentrations 
      of ET-1 (IDCM 0.76 (0.25) v controls 0.31 (0.06) fmol/ml; p = 0.002) and BET 
      (IDCM 3.58 (1.06) v controls 2.11 (0.58) fmol/ml; p = 0.014) were increased in 
      patients with IDCM. Aortic ET-1 concentrations correlated positively with NYHA 
      class (r = 0. 731; p < 0.001), myocardial oxygen consumption (r = 0.749; p < 0. 
      001), and coronary blood flow (r = 0.645; p = 0.003), but inversely with coronary 
      sinus oxygen content (r = -0.633; p = 0.004), which was significantly decreased 
      in IDCM patients (IDCM 4.68 (1.05) v controls 6.70 (1.06) vol%; p = 0.003). 
      CONCLUSIONS: The coronary circulation in patients with IDCM is exposed to an 
      increased endothelin load. ET-1 concentrations correlate with functional 
      deterioration. A decrease of the coronary sinus content of oxygen suggests a 
      mismatch between coronary blood flow and metabolic demand. Thus, ET-1 might be a 
      marker of a disequilibrium between myocardial oxygen demand and coronary blood 
      flow in IDCM.
FAU - Mundhenke, M
AU  - Mundhenke M
AD  - Division of Cardiology, Pneumology and Angiology, School of Medicine, Heinrich 
      Heine University, Moorenstrabetae 5, 40225 Dusseldorf, Germany.
FAU - Schwartzkopff, B
AU  - Schwartzkopff B
FAU - Kostering, M
AU  - Kostering M
FAU - Deska, U
AU  - Deska U
FAU - Klein, R M
AU  - Klein RM
FAU - Strauer, B E
AU  - Strauer BE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Heart
JT  - Heart (British Cardiac Society)
JID - 9602087
RN  - 0 (Biomarkers)
RN  - 0 (Endothelin-1)
RN  - 0 (Endothelins)
RN  - 0 (Protein Precursors)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Aorta
MH  - Biomarkers/blood
MH  - Cardiomyopathy, Dilated/*blood/metabolism/physiopathology
MH  - Case-Control Studies
MH  - *Coronary Circulation
MH  - Endothelin-1/blood
MH  - Endothelins/*blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardium/metabolism
MH  - Oxygen/blood
MH  - Oxygen Consumption
MH  - Protein Precursors/blood
PMC - PMC1728961
EDAT- 1999/02/23 00:00
MHDA- 1999/02/23 00:01
PMCR- 2002/03/01
CRDT- 1999/02/23 00:00
PHST- 1999/02/23 00:00 [pubmed]
PHST- 1999/02/23 00:01 [medline]
PHST- 1999/02/23 00:00 [entrez]
PHST- 2002/03/01 00:00 [pmc-release]
AID - 10.1136/hrt.81.3.278 [doi]
PST - ppublish
SO  - Heart. 1999 Mar;81(3):278-84. doi: 10.1136/hrt.81.3.278.