PMID- 10027289 OWN - NLM STAT- MEDLINE DCOM- 19990316 LR - 20190822 IS - 0896-6273 (Print) IS - 0896-6273 (Linking) VI - 22 IP - 1 DP - 1999 Jan TI - BDNF mediates the effects of testosterone on the survival of new neurons in an adult brain. PG - 53-62 AB - New neurons are incorporated into the high vocal center (HVC), a nucleus of the adult canary (Serinus canaria) brain that plays a critical role in the acquisition and production of learned song. Recruitment of new neurons in the HVC is seasonally regulated and depends upon testosterone levels. We show here that brain-derived neurotrophic factor (BDNF) is present in the HVC of adult males but is not detectable in that of females, though the HVC of both sexes has BDNF receptors (TrkB). Testosterone treatment increases the levels of BDNF protein in the female HVC, and BDNF infused into the HVC of adult females triples the number of new neurons. Infusion of a neutralizing antibody to BDNF blocks the testosterone-induced increase in new neurons. Our results demonstrate that BDNF is involved in the regulation of neuronal replacement in the adult canary brain and suggest that the effects of testosterone are mediated through BDNF. FAU - Rasika, S AU - Rasika S AD - The Rockefeller University, New York, New York 10021, USA. FAU - Alvarez-Buylla, A AU - Alvarez-Buylla A FAU - Nottebohm, F AU - Nottebohm F LA - eng PT - Journal Article PT - Research Support, U.S. Gov't, P.H.S. PL - United States TA - Neuron JT - Neuron JID - 8809320 RN - 0 (Antibodies) RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Receptor, Ciliary Neurotrophic Factor) RN - 0 (Receptors, Nerve Growth Factor) RN - 3XMK78S47O (Testosterone) RN - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases) SB - IM MH - Animals MH - Antibodies/pharmacology MH - Brain/cytology/metabolism/*physiology MH - Brain-Derived Neurotrophic Factor/immunology/metabolism/*pharmacology MH - Canaries MH - Cell Survival/drug effects MH - Female MH - Male MH - Neurons/*drug effects/physiology MH - Receptor Protein-Tyrosine Kinases/metabolism MH - Receptor, Ciliary Neurotrophic Factor MH - Receptors, Nerve Growth Factor/metabolism MH - Recruitment, Neurophysiological/physiology MH - Sex Characteristics MH - Testosterone/antagonists & inhibitors/*pharmacology MH - Vocalization, Animal/physiology EDAT- 1999/02/23 00:00 MHDA- 1999/02/23 00:01 CRDT- 1999/02/23 00:00 PHST- 1999/02/23 00:00 [pubmed] PHST- 1999/02/23 00:01 [medline] PHST- 1999/02/23 00:00 [entrez] AID - S0896-6273(00)80678-9 [pii] AID - 10.1016/s0896-6273(00)80678-9 [doi] PST - ppublish SO - Neuron. 1999 Jan;22(1):53-62. doi: 10.1016/s0896-6273(00)80678-9.