PMID- 10027549
OWN - NLM
STAT- MEDLINE
DCOM- 19990614
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 259
IP  - 1
DP  - 1999 Jan 4
TI  - Plasma levels of apolipoprotein E and genetic markers in elderly patients with 
      Alzheimer's disease.
PG  - 33-6
AB  - Besides apolipoprotein E (APOE) polymorphism, whose association with Alzheimer's 
      disease (AD) has been confirmed in most of the numerous population samples 
      studied, other markers have been investigated. In most cases the association 
      firstly described was not confirmed in subsequent works. Since it is important to 
      examine these associations in as many populations as possible, we investigated 
      APOE, APOC1, APOC2, alpha-1 antichymotrypsin (ACT) and presenilin-1 (PS-1) 
      polymorphisms in a series of elderly patients with late-onset sporadic AD from 
      Northern Italy and in a sex and age-matched control group. We could not confirm 
      the significantly higher frequency of the ACT*A allele among carriers of APOE e*4 
      allele described elsewhere, although a similar trend was observed. The APOC2 and 
      the PS-1 distributions were similar between patients and controls. However, we 
      observed a significant difference in the genotype and allele frequencies of APOE 
      and APOC1: patients had higher e*4 and C1*2 allele frequencies. This finding 
      confirms the important role for APOE in AD occurrence. In addition, APOC1 seems 
      to be an interesting marker because, though in strict linkage disequilibrium with 
      APOE, it seems to play an independent role in AD risk. In contrast to previously 
      reported data, plasma apoE concentrations were similar in patients and in 
      controls. An interaction between APOE and APOC1 polymorphisms and apoE levels was 
      observed in patients: subjects carrying the APOE E3/E2 or the APOC1 2-2 genotype 
      have higher apoE concentrations than those who do not.
FAU - Scacchi, R
AU  - Scacchi R
AD  - CNR Center of Evolutionary Genetics, Department of Genetics and Molecular 
      Biology, University La Sapienza, Rome, Italy. scacchi@axcasp.caspur.it
FAU - Gambina, G
AU  - Gambina G
FAU - Ruggeri, M
AU  - Ruggeri M
FAU - Martini, M C
AU  - Martini MC
FAU - Ferrari, G
AU  - Ferrari G
FAU - Silvestri, M
AU  - Silvestri M
FAU - Schiavon, R
AU  - Schiavon R
FAU - Corbo, R M
AU  - Corbo RM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Apolipoproteins E)
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/*blood/*genetics
MH  - Apolipoproteins E/*blood
MH  - Female
MH  - Genetic Markers
MH  - Humans
MH  - Male
EDAT- 1999/02/23 00:00
MHDA- 1999/02/23 00:01
CRDT- 1999/02/23 00:00
PHST- 1999/02/23 00:00 [pubmed]
PHST- 1999/02/23 00:01 [medline]
PHST- 1999/02/23 00:00 [entrez]
AID - S0304-3940(98)00889-1 [pii]
AID - 10.1016/s0304-3940(98)00889-1 [doi]
PST - ppublish
SO  - Neurosci Lett. 1999 Jan 4;259(1):33-6. doi: 10.1016/s0304-3940(98)00889-1.