PMID- 10027697
OWN - NLM
STAT- MEDLINE
DCOM- 19990618
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 260
IP  - 1
DP  - 1999 Jan 22
TI  - Upregulation of brain-derived neurotrophic factor and neuropeptide Y in the 
      dorsal ascending sensory pathway following sciatic nerve injury in rat.
PG  - 49-52
AB  - An immunohistochemical study was undertaken to examine the changes of 
      brain-derived neurotrophic factor (BDNF) and neuropeptide Y (NPY) in the nucleus 
      gracilis of rats following sciatic nerve transection. The results showed that 
      BDNF-immunoreactivity (-ir) in the gracile nucleus was significantly increased 
      after the nerve injury. The upregulation was apparent 24 h after nerve lesion, 
      remaining robust up to 56 days postlesion. The increase in BDNF-ir was blocked by 
      hemisection of the spinal cord, or by dorsal rhizotomy ipsilateral to the lesion. 
      NPY-ir changes were similar to those of BDNF-ir, but the onset was delayed by 7 
      days. No NPY-ir was detected in dorsal root ganglion (DRG) from normal animals. 
      Following sciatic nerve lesion, most of the NPY-immunoreactive neurones were 
      found to be colocalized with BDNF-immunoreactive neurones. Neutralization of 
      endogenous BDNF with its antiserum had no effects on NPY-ir in either the gracile 
      nucleus or DRG. These results indicate that neurones contributing to the dorsal 
      ascending sensory pathway upregulate the expression of both BDNF and NPY in 
      response to sciatic nerve injury.
FAU - Li, W P
AU  - Li WP
AD  - Department of Human Physiology and Centre for Neuroscience, Flinders University 
      of South Australia, Adelaide, Australia.
FAU - Xian, C
AU  - Xian C
FAU - Rush, R A
AU  - Rush RA
FAU - Zhou, X F
AU  - Zhou XF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Neuropeptide Y)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*physiology
MH  - Male
MH  - Neural Pathways/*physiology
MH  - Neurons, Afferent/*physiology
MH  - Neuropeptide Y/*physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Sciatic Nerve/*injuries/physiopathology
MH  - Up-Regulation/*physiology
EDAT- 1999/02/23 00:00
MHDA- 1999/02/23 00:01
CRDT- 1999/02/23 00:00
PHST- 1999/02/23 00:00 [pubmed]
PHST- 1999/02/23 00:01 [medline]
PHST- 1999/02/23 00:00 [entrez]
AID - S0304-3940(98)00958-6 [pii]
AID - 10.1016/s0304-3940(98)00958-6 [doi]
PST - ppublish
SO  - Neurosci Lett. 1999 Jan 22;260(1):49-52. doi: 10.1016/s0304-3940(98)00958-6.