PMID- 10027727
OWN - NLM
STAT- MEDLINE
DCOM- 19990322
LR  - 20201226
IS  - 0007-1048 (Print)
IS  - 0007-1048 (Linking)
VI  - 104
IP  - 1
DP  - 1999 Jan
TI  - The difference in NK-cell activity between patients with non-Hodgkin's lymphomas 
      and Hodgkin's disease.
PG  - 144-51
AB  - Natural killer (NK) cells play an important role in immune surveillance against 
      malignant diseases. Considering the lymphoid origin of malignant lymphomas, as 
      well as scarce data concerning NK-cell function in these neoplasms, we evaluated 
      NK-cell activity in 49 patients with non-Hodgkin's lymphomas (NHL) and 47 
      patients with Hodgkin's disease (HD), prior to therapy. Using the recommended 
      International Working Formulation and the Ann Arbor staging system for 
      classification of lymphomas we found, by the LDH release cytotoxicity assay, that 
      decreased NK-cell activity (P < 0.05) in NHL patients was essentially related to 
      unfavourable histology (13 indolent lymphomas, 25 intermediate and 11 very 
      aggressive lymphomas were included), but that within these categories clinical 
      stage of the disease also contributed to the degree of NK-cell dysfunction. In 
      contrast, in HD, NK-cell activity was persistently decreased (P< 0.05), compared 
      to controls, irrespective of histological type and clinical stage. It is of 
      interest also that the most profound NK-cell dysfunction that is present and 
      persistent from the onset of HD, and which appears in very aggressive NHL was 
      associated with the phenomenon of increased spontaneous lactate acid 
      dehydrogenase (LDH) release activity from the separated PBMC of these patients. 
      The difference in the level of NK-cell impairment between patients with various 
      histological grades of malignancy in NHL and HD suggests different initial 
      participation of innate immune reactions in these diseases.
FAU - Konjevic, G
AU  - Konjevic G
AD  - Institute of Oncology and Radiology of Serbia, Belgrade.
FAU - Jurisic, V
AU  - Jurisic V
FAU - Banicevic, B
AU  - Banicevic B
FAU - Spuzic, I
AU  - Spuzic I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Haematol
JT  - British journal of haematology
JID - 0372544
RN  - EC 1.1.1.27 (L-Lactate Dehydrogenase)
SB  - IM
MH  - Cytotoxicity, Immunologic
MH  - Hodgkin Disease/enzymology/*immunology/pathology
MH  - Humans
MH  - Killer Cells, Natural/enzymology/*immunology
MH  - L-Lactate Dehydrogenase/metabolism
MH  - Lymphoma, Non-Hodgkin/enzymology/*immunology/pathology
EDAT- 1999/02/23 00:00
MHDA- 1999/02/23 00:01
CRDT- 1999/02/23 00:00
PHST- 1999/02/23 00:00 [pubmed]
PHST- 1999/02/23 00:01 [medline]
PHST- 1999/02/23 00:00 [entrez]
AID - 10.1046/j.1365-2141.1999.01129.x [doi]
PST - ppublish
SO  - Br J Haematol. 1999 Jan;104(1):144-51. doi: 10.1046/j.1365-2141.1999.01129.x.