PMID- 10028376
OWN - NLM
STAT- MEDLINE
DCOM- 19990322
LR  - 20151119
IS  - 0004-4172 (Print)
IS  - 0004-4172 (Linking)
VI  - 49
IP  - 1
DP  - 1999 Jan
TI  - Effect of carbohydrate intake on serum 3,5,3'-triiodothyronine-response to 
      glucose ingestion and its relation to glucose tolerance in lean 
      non-insulin-dependent diabetic patients.
PG  - 30-4
AB  - This study was conducted to know the effect of carbohydrate intake on serum 
      3,5,3'-triiodothyronine (CAS 6893-02-3, T3)-response to glucose ingestion and its 
      relation to glucose tolerance in lean non-insulin-dependent diabetes mellitus 
      (NIDDM) patients. Ten patients, body mass index: 21.8 +/- 2.2 (mean +/- SD) 
      kg/m2, were given a control diet (2012 kcal/day(d); carbohydrate (CHO): 299 g/d) 
      on admission. Several days later, they were given a low-calorie and low-CHO diet 
      (Low-CHO) (1156 kcal/d; CHO: 139 g/d) and 2 weeks later, they received a 
      low-calorie and high-CHO diet (High-CHO) (1154 kcal/d; CHO: 176 g/d) and another 
      2 weeks later, they were given Low-CHO again for 2 weeks. They received oral 75 g 
      glucose tolerance tests after completion of each diet. sigma dGlucose (mmol/l) 
      decreased from 54.3 +/- 11.9 (control) to 42.5 +/- 7.5 after Low-CHO and reached 
      34.5 +/- 10.4 after High-CHO but increased to 36.4 +/- 11.1 after the 2nd Low-CHO 
      (F = 7.46, p = 0.0005). sigma dT3 (nmol/l) increased from -0.18 +/- 0.52 
      (control) to 0.12 +/- 0.67 after Low-CHO and reached 0.92 +/- 0.59 after High-CHO 
      but decreased to 0.36 +/- 0.65 after the 2nd Low-CHO (F = 5.92, p = 0.0022). 
      Serum insulin and body weight remained unchanged throughout the study. Negative 
      correlation between sigma dT3 and sigma dGlucose (r = -0.493, n = 40, p = 0.0012) 
      was found throughout the diet modification. Carbohydrate intake affected serum 
      T3-response to glucose ingestion and the response was closely related to glucose 
      tolerance in lean NIDDM patients.
FAU - Koh, H
AU  - Koh H
AD  - Department of Internal Medicine, National Cardiovascular Center, Osaka, Japan.
FAU - Tsushima, M
AU  - Tsushima M
FAU - Harano, Y
AU  - Harano Y
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - Germany
TA  - Arzneimittelforschung
JT  - Arzneimittel-Forschung
JID - 0372660
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Insulin)
RN  - 06LU7C9H1V (Triiodothyronine)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Blood Glucose/metabolism
MH  - Body Mass Index
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Dietary Carbohydrates/*administration & dosage
MH  - Energy Intake
MH  - Female
MH  - *Glucose
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Insulin/blood
MH  - Male
MH  - Middle Aged
MH  - Triiodothyronine/*blood
EDAT- 1999/02/24 00:00
MHDA- 1999/02/24 00:01
CRDT- 1999/02/24 00:00
PHST- 1999/02/24 00:00 [pubmed]
PHST- 1999/02/24 00:01 [medline]
PHST- 1999/02/24 00:00 [entrez]
AID - 10.1055/s-0031-1300354 [doi]
PST - ppublish
SO  - Arzneimittelforschung. 1999 Jan;49(1):30-4. doi: 10.1055/s-0031-1300354.