PMID- 10030068
OWN - NLM
STAT- MEDLINE
DCOM- 19990504
LR  - 20190516
IS  - 0034-8910 (Print)
IS  - 0034-8910 (Linking)
VI  - 32
IP  - 5
DP  - 1998 Oct
TI  - [Ecstasy: a pharmacological review].
PG  - 487-95
AB  - A literature review on 3,4 methylenedioxymethanphetaneine (MDMA), known as 
      ecstasy, a drug with increased use among youngsters is presented. The history 
      from its synthesis, up to its use as an adjunct to psychotherapy and, more 
      recently, as a drug of abuse, is described. The possible pattern of abuse in 
      several countries is reviewed with the objective of predicting what might happen 
      in Brazil, where some reports of abuse have already appeared. The 
      pharmacokinetics of MDMA is also reviewed to explain the consequences for 
      pharmacological activity, toxicology and adverse effects. The clinical outcome of 
      both short and middle-term intoxication is summarized and the clinical symptoms 
      of severe intoxication with ecstasy, are described. The studies undertaken on its 
      mechanism of action are detailed to explain its toxic psychiatric and physical 
      side effects, to explain the mechanism of self-administration of the drug and to 
      propose a therapeutic possibility of treating intoxication.
FAU - Ferigolo, M
AU  - Ferigolo M
AD  - Laboratorio de Farmacologia da Fundacao Faculdade Federal de Ciencias Medicas de 
      Porto Alegre, RS, Brasil.
FAU - Medeiros, F B
AU  - Medeiros FB
FAU - Barros, H M
AU  - Barros HM
LA  - por
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - "Extase": revisao farmacologica.
PL  - Brazil
TA  - Rev Saude Publica
JT  - Revista de saude publica
JID - 0135043
RN  - 0 (Hallucinogens)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Hallucinogens/*pharmacology
MH  - Humans
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Substance-Related Disorders
RF  - 49
EDAT- 1999/02/25 00:00
MHDA- 1999/02/25 00:01
CRDT- 1999/02/25 00:00
PHST- 1999/02/25 00:00 [pubmed]
PHST- 1999/02/25 00:01 [medline]
PHST- 1999/02/25 00:00 [entrez]
AID - 10.1590/s0034-89101998000500014 [doi]
PST - ppublish
SO  - Rev Saude Publica. 1998 Oct;32(5):487-95. doi: 10.1590/s0034-89101998000500014.