PMID- 10030291
OWN - NLM
STAT- MEDLINE
DCOM- 19990311
LR  - 20190713
IS  - 0041-1337 (Print)
IS  - 0041-1337 (Linking)
VI  - 67
IP  - 3
DP  - 1999 Feb 15
TI  - Histological outcome of acute cellular rejection in kidney transplantation after 
      treatment with methylprednisolone.
PG  - 430-4
AB  - BACKGROUND: Several studies comparing the response of acute cellular rejection 
      (ACR) episodes to different corticosteroid regimens have been conducted. However, 
      in most of them, the histological evaluation of the infiltrate and its 
      correlation with clinical response was not studied. The clinical and histological 
      outcomes of 37 episodes of ACR treated with methylprednisolone (MP) were studied, 
      with the aim to determine how long the infiltrate takes to be cleared after 
      therapy. METHODS: A total of 37 patients with biopsy-proven ACR were treated with 
      8 or 16 mg of MP/kg/day. Allograft biopsies were repeated at 5 and 10 days after 
      the end of corticotherapy. Clinical and histological outcomes were compared. 
      RESULTS: Six patients were excluded; 15 (48.4%) patients responded to therapy; 
      the mean serum creatinine of these patients reached normal levels in the 2 weeks 
      that followed treatment. Nine patients (60%) of this group had signs of ACR on 
      biopsies done 5 days after corticotherapy, and four (26.7%) maintained them on 
      the 10th day. Among 16 patients with no clinical response, none reached normal 
      serum creatinine levels; 15 (93.7%) had signs of rejection 5 days after treatment 
      and maintained them on the 10th day. Histological signs of ACR disappeared in 
      73.3% of patients with clinical response 10 days after therapy, but in only 6.3% 
      of patients with no response (P=0.001). CONCLUSIONS: Biopsies performed 5 days 
      after treatment show a high incidence of features of ACR; such features take on 
      average 10 days to disappear in nearly 75% of cases with successful therapy with 
      MP.
FAU - Mazzucchi, E
AU  - Mazzucchi E
AD  - Division of Urology, Clinicas Hospital, University of Sao Paulo Medical School, 
      Brazil.
FAU - Lucon, A M
AU  - Lucon AM
FAU - Nahas, W C
AU  - Nahas WC
FAU - Neto, E D
AU  - Neto ED
FAU - Saldanha, L B
AU  - Saldanha LB
FAU - Sabbaga, E
AU  - Sabbaga E
FAU - Ianhez, L E
AU  - Ianhez LE
FAU - Arap, S
AU  - Arap S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplantation
JT  - Transplantation
JID - 0132144
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Immunosuppressive Agents)
RN  - 83HN0GTJ6D (Cyclosporine)
RN  - X4W7ZR7023 (Methylprednisolone)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Anti-Inflammatory Agents/*therapeutic use
MH  - Chi-Square Distribution
MH  - Cyclosporine/*therapeutic use
MH  - Graft Rejection/*drug therapy/immunology/*pathology
MH  - Graft Survival
MH  - Humans
MH  - Immunosuppressive Agents/*therapeutic use
MH  - Kidney Transplantation/*immunology/pathology/physiology
MH  - Methylprednisolone/*therapeutic use
MH  - Middle Aged
MH  - Retrospective Studies
EDAT- 1999/02/25 00:00
MHDA- 1999/02/25 00:01
CRDT- 1999/02/25 00:00
PHST- 1999/02/25 00:00 [pubmed]
PHST- 1999/02/25 00:01 [medline]
PHST- 1999/02/25 00:00 [entrez]
AID - 10.1097/00007890-199902150-00016 [doi]
PST - ppublish
SO  - Transplantation. 1999 Feb 15;67(3):430-4. doi: 10.1097/00007890-199902150-00016.