PMID- 1003099
OWN - NLM
STAT- MEDLINE
DCOM- 19770216
LR  - 20190508
IS  - 0022-1007 (Print)
IS  - 1540-9538 (Electronic)
IS  - 0022-1007 (Linking)
VI  - 144
IP  - 6
DP  - 1976 Dec 1
TI  - 2-Deoxyglucose selectively inhibits Fc and complement receptor-mediated 
      phagocytosis in mouse peritoneal macrophages II. Dissociation of the inhibitory 
      effects of 2-deoxyglucose on phagocytosis and ATP generation.
PG  - 1484-93
AB  - Macrophages incubated in 2-deoxy-D-glucose (2-dG)-containing medium showed a 
      marked decrease in cellular ATP content, and were unable to ingest IgG- and 
      complement-coated erythrocytes via the corresponding membrane receptors for these 
      ligands. However, the inhibitory effects of 2-dG on Fc- and C3 receptor-mediated 
      phagocytosis were not a consequence of lowered macrophage ATP levels since 
      addition of glucose or mannose to the culture medium restored the capacity of the 
      macrophages to ingest IgG- and C3-coated particles without increasing ATP levels. 
      These results indicate that Fc- and C3 receptor-mediated phagocytosis (opsonin 
      dependent) differs qualitatively from the ingestion of latex and zymosan 
      particles (opsonin independent); they suggest that the same regulatory molecules 
      govern the responses of phagocytic cells to signals initiated by both the Fc and 
      C3 receptors. The possibility that these molecules are regulated by glycosylation 
      is discussed.
FAU - Michl, J
AU  - Michl J
FAU - Ohlbaum, D J
AU  - Ohlbaum DJ
FAU - Silverstein, S C
AU  - Silverstein SC
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Exp Med
JT  - The Journal of experimental medicine
JID - 2985109R
RN  - 0 (Complement C3)
RN  - 0 (Deoxy Sugars)
RN  - 0 (Immunoglobulin Fc Fragments)
RN  - 0 (Opsonin Proteins)
RN  - 0 (Thioglycolates)
RN  - 8L70Q75FXE (Adenosine Triphosphate)
RN  - 9007-36-7 (Complement System Proteins)
RN  - 9G2MP84A8W (Deoxyglucose)
SB  - IM
MH  - Adenosine Triphosphate/*metabolism
MH  - Animals
MH  - Ascitic Fluid/cytology
MH  - Binding Sites/drug effects
MH  - Complement C3/*metabolism
MH  - Complement System Proteins/*metabolism
MH  - Deoxy Sugars/*pharmacology
MH  - Deoxyglucose/*pharmacology
MH  - *Immunoglobulin Fc Fragments
MH  - Macrophages/drug effects/metabolism/*physiology
MH  - Mice
MH  - Opsonin Proteins
MH  - Phagocytosis/*drug effects
MH  - Thioglycolates
PMC - PMC2190489
EDAT- 1976/12/01 00:00
MHDA- 1976/12/01 00:01
PMCR- 1977/06/01
CRDT- 1976/12/01 00:00
PHST- 1976/12/01 00:00 [pubmed]
PHST- 1976/12/01 00:01 [medline]
PHST- 1976/12/01 00:00 [entrez]
PHST- 1977/06/01 00:00 [pmc-release]
AID - 77073100 [pii]
AID - 10.1084/jem.144.6.1484 [doi]
PST - ppublish
SO  - J Exp Med. 1976 Dec 1;144(6):1484-93. doi: 10.1084/jem.144.6.1484.