PMID- 10036183
OWN - NLM
STAT- MEDLINE
DCOM- 19990505
LR  - 20101118
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 56
IP  - 1
DP  - 1999 Feb 15
TI  - High-resolution human/goat comparative map of the goat polled/intersex syndrome 
      (PIS): the human homologue is contained in a human YAC from HSA3q23.
PG  - 31-9
AB  - The genetic and cytogenetic map around the chromosome 1 region shown to be linked 
      with polledness and intersexuality (PIS) in the domestic goat (Capra hircus) was 
      refined. For this purpose, a goat BAC library was systematically screened with 
      primers from human coding sequences, scraped chromosome 1 DNA, bovine 
      microsatellites from the region, and BAC ends. All the BACs (n = 30) were mapped 
      by fluorescence in situ hybridization (FISH) on goat chromosome 1q41-q45. The 
      genetic mapping of 30 new goat polymorphic markers, isolated from these BACs, 
      made it possible to reduce the PIS interval to a region of less than 1 cM on goat 
      chromosome 1q43. The PIS locus is now located between the two genes ATP1B and 
      COP, which both map to 3q23 in humans. Genetic, cytogenetic, and comparative data 
      suggest that the PIS region is now probably circumscribed to an approximately 
      1-Mb DNA segment for which construction of a BAC contig is in progress. In 
      addition, a human YAC contig encompassing the 
      blepharophimosis-ptosis-epicanthus-inversus region was mapped by FISH to goat 
      chromosome 1q43. This human disease, mapped to HSA 3q23 and affecting the 
      development and maintenance of ovarian function, could be a potential candidate 
      for goat PIS.
CI  - Copyright 1999 Academic Press.
FAU - Vaiman, D
AU  - Vaiman D
AD  - Departement de Genetique Animale, INRA, Jouy-en-Josas, 78352, France. 
      vaiman@biotec.jouy.inra.fr
FAU - Schibler, L
AU  - Schibler L
FAU - Oustry-Vaiman, A
AU  - Oustry-Vaiman A
FAU - Pailhoux, E
AU  - Pailhoux E
FAU - Goldammer, T
AU  - Goldammer T
FAU - Stevanovic, M
AU  - Stevanovic M
FAU - Furet, J P
AU  - Furet JP
FAU - Schwerin, M
AU  - Schwerin M
FAU - Cotinot, C
AU  - Cotinot C
FAU - Fellous, M
AU  - Fellous M
FAU - Cribiu, E P
AU  - Cribiu EP
LA  - eng
SI  - GENBANK/G41201
SI  - GENBANK/G41202
SI  - GENBANK/G41203
SI  - GENBANK/G41204
SI  - GENBANK/G41205
SI  - GENBANK/G41206
SI  - GENBANK/G41207
SI  - GENBANK/G41208
SI  - GENBANK/G41209
SI  - GENBANK/G41210
SI  - GENBANK/G41211
SI  - GENBANK/G41212
SI  - GENBANK/G41213
SI  - GENBANK/G41214
SI  - GENBANK/G41215
SI  - GENBANK/G41216
SI  - GENBANK/G41217
SI  - GENBANK/G41218
SI  - GENBANK/G41219
SI  - GENBANK/G41220
SI  - GENBANK/G41221
SI  - GENBANK/G41222
SI  - GENBANK/G41223
SI  - GENBANK/G41224
SI  - GENBANK/G41225
SI  - GENBANK/G41226
SI  - GENBANK/G41227
SI  - GENBANK/G41228
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Animals
MH  - Cattle
MH  - Chromosome Mapping
MH  - Chromosomes, Artificial, Yeast
MH  - Chromosomes, Human, Pair 3/*genetics
MH  - Disorders of Sex Development/*genetics
MH  - Genetic Markers
MH  - Goats/*genetics
MH  - Humans
MH  - Molecular Sequence Data
MH  - Polymorphism, Restriction Fragment Length
MH  - Recombination, Genetic
MH  - Sequence Homology, Nucleic Acid
MH  - Syndrome
EDAT- 1999/02/26 00:00
MHDA- 1999/02/26 00:01
CRDT- 1999/02/26 00:00
PHST- 1999/02/26 00:00 [pubmed]
PHST- 1999/02/26 00:01 [medline]
PHST- 1999/02/26 00:00 [entrez]
AID - S0888-7543(98)95691-9 [pii]
AID - 10.1006/geno.1998.5691 [doi]
PST - ppublish
SO  - Genomics. 1999 Feb 15;56(1):31-9. doi: 10.1006/geno.1998.5691.