PMID- 10036256
OWN - NLM
STAT- MEDLINE
DCOM- 19990817
LR  - 20171213
IS  - 0022-3077 (Print)
IS  - 0022-3077 (Linking)
VI  - 81
IP  - 2
DP  - 1999 Feb
TI  - C-PR neuron of Aplysia has differential effects on "Feeding" cerebral 
      interneurons, including myomodulin-positive CBI-12.
PG  - 521-34
AB  - Head lifting and other aspects of the appetitive central motive state that 
      precedes consummatory feeding movements in Aplysia is promoted by excitation of 
      the C-PR neuron. Food stimuli activate C-PR as well as a small population of 
      cerebral-buccal interneurons (CBIs). We wished to determine if firing of C-PR 
      produced differential effects on the various CBIs or perhaps affected all the 
      CBIs uniformly as might be expected for a neuron involved in producing a broad 
      undifferentiated arousal state. We found that when C-PR was fired, it produced a 
      wide variety of effects on various CBIs. Firing of C-PR evoked excitatory input 
      to a newly identified CBI (CBI-12) the soma of which is located in the M cluster 
      near the previously identified CBI-2. CBI-12 shares certain properties with 
      CBI-2, including a similar morphology and a capacity to drive rhythmic activity 
      of the buccal-ganglion. Unlike CBI-2, CBI-12 exhibits myomodulin 
      immunoreactivity. Furthermore when C-PR is fired, CBI-12 receives a polysynaptic 
      voltage-dependent slow excitation, whereas, CBI-2 receives relatively little 
      input. C-PR also polysynaptically excites other CBIs including CBI-1 and CBI-8/9 
      but produces inhibition in CBI-3. In addition, firing of C-PR inhibits plateau 
      potentials in CBI-5/6. The data suggest that activity of C-PR may promote the 
      activity of one subset of cerebral-buccal interneurons, perhaps those involved in 
      ingestive behaviors that occur during the head-up posture. C-PR also inhibits 
      some cerebral-buccal interneurons that may be involved in behaviors in which C-PR 
      activity is not required or may even interfere with other feeding behaviors such 
      as rejection or grazing, that occur with the head down.
FAU - Hurwitz, I
AU  - Hurwitz I
AD  - Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York 
      10029, USA.
FAU - Perrins, R
AU  - Perrins R
FAU - Xin, Y
AU  - Xin Y
FAU - Weiss, K R
AU  - Weiss KR
FAU - Kupfermann, I
AU  - Kupfermann I
LA  - eng
GR  - GM-320099/GM/NIGMS NIH HHS/United States
GR  - MH-36730/MH/NIMH NIH HHS/United States
GR  - MH-50235/MH/NIMH NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Neurophysiol
JT  - Journal of neurophysiology
JID - 0375404
RN  - 0 (Neuropeptides)
RN  - 110570-93-9 (myomodulin)
SB  - IM
MH  - Animals
MH  - Aplysia
MH  - Cell Size/physiology
MH  - Central Nervous System/*physiology
MH  - Evoked Potentials/physiology
MH  - Feeding Behavior/*physiology
MH  - Ganglia, Invertebrate/physiology
MH  - In Vitro Techniques
MH  - Interneurons/cytology/metabolism/*physiology
MH  - Neural Inhibition/physiology
MH  - Neural Pathways/physiology
MH  - Neurons/cytology/*physiology
MH  - Neuropeptides/*metabolism
MH  - Patch-Clamp Techniques
EDAT- 1999/02/26 00:00
MHDA- 1999/02/26 00:01
CRDT- 1999/02/26 00:00
PHST- 1999/02/26 00:00 [pubmed]
PHST- 1999/02/26 00:01 [medline]
PHST- 1999/02/26 00:00 [entrez]
AID - 10.1152/jn.1999.81.2.521 [doi]
PST - ppublish
SO  - J Neurophysiol. 1999 Feb;81(2):521-34. doi: 10.1152/jn.1999.81.2.521.