PMID- 10036927
OWN - NLM
STAT- MEDLINE
DCOM- 19990415
LR  - 20151008
IS  - 0029-0203 (Print)
IS  - 0029-0203 (Linking)
VI  - 103
IP  - 1
DP  - 1999 Jan
TI  - [A report of two cases suggesting positive influence of pregnancy on uveitis 
      activity].
PG  - 66-71
AB  - BACKGROUND: Little is known about the influence of pregnancy on uveitis activity. 
      We report two cases suggesting a favorable influence of pregnancy on the clinical 
      course of uveitis. CASE: A 30-year-old woman who was three months pregnant was 
      suspected Vogt-Koyanagi-Harada disease based on the systemic symptoms and ocular 
      findings of iritis and multi-focal serous retinal detachment. She was positive to 
      human leukocyte antigen (HLA)-DR 4. She was treated only with topical 
      corticosteroids. One month later, the retinal detachment disappeared. Six month 
      later, a healthy baby was born. The fundus of both eyes took on a sunset glow 
      appearance and there has been no recurrence of uveitis. The other case was a 
      23-year-old woman with Behcet's disease who had several episodes of uveitis in a 
      year even on tacrolimus. Because of pregnancy, all systemic drugs including 
      tacrolimus were discontinued since then. Interestingly, the frequency of uveitis 
      was remarkably decreased during the pregnancy. A normal healthy baby was born. 
      The uveitis has almost completely disappeared since parturition until now. 
      CONCLUSION: It is considered that the increase of intrinsic hormone, especially 
      corticosteroid, and some other factors with pregnancy may give the suppressive 
      influence on uveitis in our cases.
FAU - Taguchi, C
AU  - Taguchi C
AD  - Department of Ophthalmology, Kurume University School of Medicine, Japan.
FAU - Ikeda, E
AU  - Ikeda E
FAU - Hikita, N
AU  - Hikita N
FAU - Mochizuki, M
AU  - Mochizuki M
LA  - jpn
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Nippon Ganka Gakkai Zasshi
JT  - Nippon Ganka Gakkai zasshi
JID - 7505716
SB  - IM
MH  - Adult
MH  - Female
MH  - Humans
MH  - Pregnancy
MH  - Pregnancy Complications/*physiopathology
MH  - Remission, Spontaneous
MH  - Uveitis/*physiopathology
EDAT- 1999/02/26 00:00
MHDA- 1999/02/26 00:01
CRDT- 1999/02/26 00:00
PHST- 1999/02/26 00:00 [pubmed]
PHST- 1999/02/26 00:01 [medline]
PHST- 1999/02/26 00:00 [entrez]
PST - ppublish
SO  - Nippon Ganka Gakkai Zasshi. 1999 Jan;103(1):66-71.