PMID- 10037083
OWN - NLM
STAT- MEDLINE
DCOM- 19990419
LR  - 20190905
IS  - 0022-0736 (Print)
IS  - 0022-0736 (Linking)
VI  - 32
IP  - 1
DP  - 1999 Jan
TI  - Exercise-induced ST elevation in patients with arrhythmogenic right ventricular 
      dysplasia.
PG  - 1-5
AB  - To test the hypothesis that local or diffuse wall motion abnormalities in the 
      right ventricle in patients with arrhythmogenic right ventricular dysplasia 
      (ARVD) may induce the ST-segment elevation in response to exercise, we examined 
      exercise electrocardiograms in patients with ARVD. In 17 patients with ARVD, who 
      demonstrated right ventricular wall motion abnormalities without organic coronary 
      lesions, we conducted a treadmill exercise test. Significant exercise-induced 
      ST-segment elevation (ESTE) was defined as a 0.1 mV or more ST-segment elevation 
      at J point. ESTE was observed in 11 patients (65%). It manifested most frequently 
      in right-sided precordial leads. Severe right ventricular asynergy was seen in 
      all but one (91%) among 11 with ESTE, whereas it was seen only in two (33%) among 
      six without ESTE (P<.05). The maximal magnitude of ESTE inversely correlated with 
      right ventricular ejection fraction (r = -0.58, P<.05). ESTE was seen in two 
      thirds of ARVD patients, helping us noninvasively diagnose ARVD. The fact that 
      ventricular wall motion abnormalities could cause ESTE in the absence of organic 
      coronary lesions suggested the critical role of mechanical factors in the genesis 
      of ESTE.
FAU - Toyofuku, M
AU  - Toyofuku M
AD  - Department of Cardiovascular Dynamics, Research Institute, National 
      Cardiovascular Center, Suita, Osaka, Japan.
FAU - Takaki, H
AU  - Takaki H
FAU - Sunagawa, K
AU  - Sunagawa K
FAU - Kurita, T
AU  - Kurita T
FAU - Shimizu, W
AU  - Shimizu W
FAU - Suyama, K
AU  - Suyama K
FAU - Aihara, N
AU  - Aihara N
FAU - Kamakura, S
AU  - Kamakura S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Electrocardiol
JT  - Journal of electrocardiology
JID - 0153605
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Arrhythmogenic Right Ventricular Dysplasia/diagnosis/*physiopathology
MH  - Coronary Angiography
MH  - *Electrocardiography
MH  - Exercise Test
MH  - Female
MH  - Heart Rate
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Contraction
MH  - Radionuclide Ventriculography
MH  - Stroke Volume
EDAT- 1999/02/26 00:00
MHDA- 1999/02/26 00:01
CRDT- 1999/02/26 00:00
PHST- 1999/02/26 00:00 [pubmed]
PHST- 1999/02/26 00:01 [medline]
PHST- 1999/02/26 00:00 [entrez]
AID - S0022-0736(99)90015-8 [pii]
AID - 10.1016/s0022-0736(99)90015-8 [doi]
PST - ppublish
SO  - J Electrocardiol. 1999 Jan;32(1):1-5. doi: 10.1016/s0022-0736(99)90015-8.