PMID- 10037216
OWN - NLM
STAT- MEDLINE
DCOM- 19990419
LR  - 20220321
IS  - 0385-5600 (Print)
IS  - 0385-5600 (Linking)
VI  - 42
IP  - 12
DP  - 1998
TI  - Detection of genes encoding cholera toxin (CT), zonula occludens toxin (ZOT), 
      accessory cholera enterotoxin (ACE) and heat-stable enterotoxin (ST) in Vibrio 
      mimicus clinical strains.
PG  - 823-8
AB  - A total of 51 clinical strains of Vibrio mimicus were searched for the presence 
      of virulence-associated genes, like ctx, zot or ace genes which locate in 
      "cholera virulence cassette," and the st gene by polymerase chain reaction. 
      Moreover, the pathological potential of each clinical strain was also examined by 
      rabbit ileal loop (RIL). Three strains showed to have the ctx gene, of which only 
      one strain was zot gene-positive. Meanwhile, one other strain was zot+ but ctx-. 
      All of these four strains were found to have the ace gene and to belong to 
      serogroup O115. Nine strains showed to carry the st gene. However, none of these 
      ST-gene-positive strains was indicated to contain the genes located in the 
      "cholera virulence cassette." It is of interest to note that all of the 
      RIL-positive and/or virulence gene-positive strains were restricted to three 
      serogroups, O20, O41 and O115. These results suggest a significant association 
      between O antigens and enterotoxic activities in V. mimicus clinical strains, and 
      clearly demonstrate multifactorial virulence potentials of this human pathogen.
FAU - Shi, L
AU  - Shi L
AD  - Faculty of Pharmaceutical Sciences, Okayama University, Okayama, Japan. 
      d09307@pheasant.pharm.okayama-u.ac.jp
FAU - Miyoshi, S
AU  - Miyoshi S
FAU - Hiura, M
AU  - Hiura M
FAU - Tomochika, K
AU  - Tomochika K
FAU - Shimada, T
AU  - Shimada T
FAU - Shinoda, S
AU  - Shinoda S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - Microbiol Immunol
JT  - Microbiology and immunology
JID - 7703966
RN  - 0 (Ace toxin)
RN  - 0 (Endotoxins)
RN  - 0 (Enterotoxins)
RN  - 100007-57-6 (enterotoxin, Vibrio mimicus)
RN  - 146481-28-9 (zonula occludens toxin, Vibrio cholerae)
RN  - 9012-63-9 (Cholera Toxin)
SB  - IM
MH  - Animals
MH  - Cholera Toxin/*genetics
MH  - Diarrhea/*microbiology
MH  - Endotoxins
MH  - Enterotoxins/*genetics
MH  - *Genes, Bacterial
MH  - Humans
MH  - Rabbits
MH  - Vibrio/*genetics/isolation & purification
EDAT- 1999/02/26 00:00
MHDA- 1999/02/26 00:01
CRDT- 1999/02/26 00:00
PHST- 1999/02/26 00:00 [pubmed]
PHST- 1999/02/26 00:01 [medline]
PHST- 1999/02/26 00:00 [entrez]
AID - 10.1111/j.1348-0421.1998.tb02357.x [doi]
PST - ppublish
SO  - Microbiol Immunol. 1998;42(12):823-8. doi: 10.1111/j.1348-0421.1998.tb02357.x.