PMID- 10048125
OWN - NLM
STAT- MEDLINE
DCOM- 19990506
LR  - 20100917
IS  - 1096-6080 (Print)
IS  - 1096-0929 (Linking)
VI  - 46
IP  - 2
DP  - 1998 Dec
TI  - Dose-response relationships for disposition and hepatic sequestration of 
      polyhalogenated dibenzo-p-dioxins, dibenzofurans, and biphenyls following 
      subchronic treatment in mice.
PG  - 223-34
AB  - Humans are exposed to mixtures of polyhalogenated dibenzo-p-dioxins, 
      dibenzofurans, and biphenyls mainly through the diet. Many of these chemicals are 
      dioxin-like and their relative toxicity is related to their ability to bind and 
      activate the Ah receptor. The present study examines the structure-activity 
      relationship for disposition of these chemicals in female B6C3F1 mice following 
      subchronic exposures. Mice were treated 5 days/week for 13 weeks by oral gavage 
      with different doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 
      1,2,3,7,8-pentachlorodibenzo-p-dioxin (PeCDD),2,3,7,8-tetrabromodibenzo-p-dioxin 
      (TBDD), 2,3,7,8-tetrachlorodibenzofuran (TCDF), 1,2,3,7,8-pentachlorodibenzofuran 
      (1-PeCDF), 2,3,4,7,8-pentachlorodibenzofuran (4-PeCDF), octachlorodibenzofuran 
      (OCDF), 3,3',4,4',5-pentachlorobiphenyl (126), 3,3',4,4',5,5'-hexachlorobiphenyl 
      (169), 2,3,3',4,4'-pentachlorobiphenyl (105), 2,3',4,4',5-pentachlorobiphenyl 
      (118), and 2,3,3',4,4',5-hexachlorobiphenyl (156). All of the chemicals examined 
      exhibited dose-dependent increases in the liver/fat concentrations except PCBs 
      105, 118, and 156. While TCDD is the most potent toxicant in this class of 
      chemicals, 4-PeCDF, PeCDD, OCDF, TCDF, and PCB126 were sequestered in hepatic 
      tissue to a greater extent than was TCDD. The high affinity for hepatic tissue 
      supports the presence of an inducible hepatic binding protein for some dixin-like 
      chemicals. The differences in disposition between these chemicals suggests that 
      pharmacokinetic differences between congeners is important in the relative 
      potency of these chemicals.
FAU - DeVito, M J
AU  - DeVito MJ
AD  - Experimental Toxicology Division, National Health and Environmental Effects 
      Research Laboratory, U.S. Environmental Protection Agency, Research Triangle 
      Park, North Carolina 27711, USA.
FAU - Ross, D G
AU  - Ross DG
FAU - Dupuy, A E Jr
AU  - Dupuy AE Jr
FAU - Ferrario, J
AU  - Ferrario J
FAU - McDaniel, D
AU  - McDaniel D
FAU - Birnbaum, L S
AU  - Birnbaum LS
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Toxicol Sci
JT  - Toxicological sciences : an official journal of the Society of Toxicology
JID - 9805461
RN  - 0 (Benzofurans)
RN  - 0 (Biphenyl Compounds)
RN  - 0 (Dioxins)
RN  - EC 1.14.14.1 (Cytochrome P-450 CYP1A2)
SB  - IM
MH  - Animals
MH  - Benzofurans/*pharmacokinetics
MH  - Biphenyl Compounds/*pharmacokinetics
MH  - Body Burden
MH  - Cytochrome P-450 CYP1A2/physiology
MH  - Dioxins/*pharmacokinetics
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - *Lipid Metabolism
MH  - Liver/drug effects/*metabolism
MH  - Mice
MH  - Time Factors
EDAT- 1999/02/27 03:14
MHDA- 2001/03/28 10:01
CRDT- 1999/02/27 03:14
PHST- 1999/02/27 03:14 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1999/02/27 03:14 [entrez]
AID - S1096-6080(98)92530-6 [pii]
AID - 10.1006/toxs.1998.2530 [doi]
PST - ppublish
SO  - Toxicol Sci. 1998 Dec;46(2):223-34. doi: 10.1006/toxs.1998.2530.