PMID- 10048467
OWN - NLM
STAT- MEDLINE
DCOM- 19990421
LR  - 20190921
IS  - 0953-8194 (Print)
IS  - 0953-8194 (Linking)
VI  - 11
IP  - 2
DP  - 1999 Feb
TI  - The effect of stressor controllability on stress-induced neuropeptide mRNA 
      expression within the paraventricular nucleus of the hypothalamus.
PG  - 121-8
AB  - Many stressors elicit changes in corticotrophin (CRH), enkephalin (ENK), and 
      neurotensin (NT) mRNA levels within the medial parvocellular region of the 
      paraventricular nucleus of the hypothalamus (mpPVN), and the pattern of changes 
      in mRNA levels appears to depend on the physical characteristics of the stressor. 
      We questioned whether psychologically distinct stressors would cause different 
      patterns of neuropeptide mRNA expression within the PVN. Psychologically distinct 
      stressors were created by employing a paradigm of escapable (controllable) vs. 
      non-escapable (yoked) tail shock. An adult male rats could terminate the stress 
      stimulus by performing wheel-turning behaviour; his behaviour also terminated the 
      stress for his yoked partner, who had no control over the termination of the 
      shock. Four h post-stress, brains were collected and processed for in-situ 
      hybridization histochemistry. Tail-shock stress stimulated a significant increase 
      in CRH, ENK, and NT mRNA levels within the mpPVN. The number of CRH identified 
      neurones coexpressing AVP mRNA was also significantly elevated in both stress 
      groups. Moreover, the pattern and magnitude of the stress-induced increases in 
      mRNA was similar in both stress groups. Additionally, no stress-induced changes 
      in CRH mRNA levels were observed in the central nucleus of the amygdala. In sum, 
      two psychologically distinct stressors, escapable vs. yoked tail shock stress, 
      stimulated similar increases in CRH, NT, ENK, and AVP mRNA levels within the 
      mpPVN. These results suggest that physical attributes of a stress, rather than 
      psychological, may be the more important factors in determining the PVN mRNA 
      response.
FAU - Helmreich, D L
AU  - Helmreich DL
AD  - University of Michigan, Ann Arbor, USA. dlhelm@umich.edu
FAU - Watkins, L R
AU  - Watkins LR
FAU - Deak, T
AU  - Deak T
FAU - Maier, S F
AU  - Maier SF
FAU - Akil, H
AU  - Akil H
FAU - Watson, S J
AU  - Watson SJ
LA  - eng
GR  - MH10715/MH/NIMH NIH HHS/United States
GR  - MH42251/MH/NIMH NIH HHS/United States
GR  - MH50479/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Neuroendocrinol
JT  - Journal of neuroendocrinology
JID - 8913461
RN  - 0 (Enkephalins)
RN  - 0 (Neuropeptides)
RN  - 0 (RNA, Messenger)
RN  - 113-79-1 (Arginine Vasopressin)
RN  - 39379-15-2 (Neurotensin)
RN  - 9015-71-8 (Corticotropin-Releasing Hormone)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Animals
MH  - Arginine Vasopressin/genetics
MH  - Corticosterone/blood
MH  - Corticotropin-Releasing Hormone/genetics
MH  - Enkephalins/genetics
MH  - Gene Expression/physiology
MH  - In Situ Hybridization
MH  - Male
MH  - Neuropeptides/*genetics
MH  - Neurotensin/genetics
MH  - Paraventricular Hypothalamic Nucleus/*physiology
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Stress, Physiological/*physiopathology
EDAT- 1999/02/27 00:00
MHDA- 1999/02/27 00:01
CRDT- 1999/02/27 00:00
PHST- 1999/02/27 00:00 [pubmed]
PHST- 1999/02/27 00:01 [medline]
PHST- 1999/02/27 00:00 [entrez]
AID - 10.1046/j.1365-2826.1999.00300.x [doi]
PST - ppublish
SO  - J Neuroendocrinol. 1999 Feb;11(2):121-8. doi: 10.1046/j.1365-2826.1999.00300.x.