PMID- 10051741
OWN - NLM
STAT- MEDLINE
DCOM- 19990421
LR  - 20190815
IS  - 0953-816X (Print)
IS  - 0953-816X (Linking)
VI  - 11
IP  - 2
DP  - 1999 Feb
TI  - Role of retinoids in the CNS: differential expression of retinoid binding 
      proteins and receptors and evidence for presence of retinoic acid.
PG  - 407-16
AB  - Retinoic acid (RA), a retinoid metabolite, acts as a gene regulator via 
      ligand-activated transcription factors, known as retinoic acid receptors (RARs) 
      and retinoid X receptors (RXRs), both existing in three different subtypes, 
      alpha, beta and gamma. In the intracellular regulation of retinoids, four binding 
      proteins have been implicated: cellular retinol binding protein (CRBP) types I 
      and II and cellular retinoic acid binding protein (CRABP) types I and II. We have 
      used in situ hybridization to localize mRNA species encoding CRBP- and CRABP I 
      and II as well as all the different nuclear receptors in the developing and adult 
      rat and mouse central nervous system (CNS), an assay to investigate the possible 
      presence of RA, and immunohistochemistry to also analyse CRBP I- and CRABP 
      immunoreactivity (IR). RXRbeta is found in most areas while RARalpha and -beta 
      and RXRalpha and -gamma show much more restricted patterns of expression. 
      RARalpha is found in cortex and hippocampus and RARbeta and RXRgamma are both 
      highly expressed in the dopamine-innervated areas caudate/putamen, nucleus 
      accumbens and olfactory tubercle. RARgamma could not be detected in any part of 
      the CNS. Using an in vitro reporter assay, we found high levels of RA in the 
      developing striatum. The caudate/putamen of the developing brain showed strong 
      CRBP I-IR in a compartmentalized manner, while at the same time containing many 
      evenly distributed CRABP I-IR neurons. The CRBP I- and CRABP I-IR patterns were 
      closely paralleled by the presence of the corresponding transcripts. The specific 
      expression pattern of retinoid-binding proteins and nuclear retinoid receptors as 
      well as the presence of RA in striatum suggests that retinoids are important in 
      many brain structures and emphasizes a role for retinoids in gene regulatory 
      events in postnatal and adult striatum.
FAU - Zetterstrom, R H
AU  - Zetterstrom RH
AD  - Department of Neuroscience, Karolinska Institute, Stockholm, Sweden. 
      Rolf.Zetterstrom@neuro.ki.se
FAU - Lindqvist, E
AU  - Lindqvist E
FAU - Mata de Urquiza, A
AU  - Mata de Urquiza A
FAU - Tomac, A
AU  - Tomac A
FAU - Eriksson, U
AU  - Eriksson U
FAU - Perlmann, T
AU  - Perlmann T
FAU - Olson, L
AU  - Olson L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
RN  - 0 (Oligonucleotide Probes)
RN  - 0 (RBP1 protein, human)
RN  - 0 (RNA, Messenger)
RN  - 0 (Rbp1 protein, rat)
RN  - 0 (Receptors, Retinoic Acid)
RN  - 0 (Retinoid X Receptors)
RN  - 0 (Retinol-Binding Proteins)
RN  - 0 (Retinol-Binding Proteins, Cellular)
RN  - 0 (Transcription Factors)
RN  - 0 (retinoic acid binding protein I, cellular)
RN  - 0 (retinoic acid binding protein II, cellular)
RN  - 5688UTC01R (Tretinoin)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Brain Chemistry/*genetics
MH  - Choriocarcinoma
MH  - Corpus Striatum/chemistry/growth & development/physiology
MH  - *Gene Expression Regulation, Developmental
MH  - Hippocampus/chemistry/growth & development/physiology
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Olfactory Pathways/chemistry/growth & development/physiology
MH  - Oligonucleotide Probes
MH  - RNA, Messenger/analysis
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Retinoic Acid/analysis/*genetics
MH  - Retinoid X Receptors
MH  - Retinol-Binding Proteins/analysis/genetics
MH  - Retinol-Binding Proteins, Cellular
MH  - Transcription Factors/analysis/*genetics
MH  - Tretinoin/*analysis/*physiology
MH  - Tumor Cells, Cultured
EDAT- 1999/03/03 00:00
MHDA- 1999/03/03 00:01
CRDT- 1999/03/03 00:00
PHST- 1999/03/03 00:00 [pubmed]
PHST- 1999/03/03 00:01 [medline]
PHST- 1999/03/03 00:00 [entrez]
AID - 10.1046/j.1460-9568.1999.00444.x [doi]
PST - ppublish
SO  - Eur J Neurosci. 1999 Feb;11(2):407-16. doi: 10.1046/j.1460-9568.1999.00444.x.