PMID- 10053012
OWN - NLM
STAT- MEDLINE
DCOM- 19990420
LR  - 20220223
IS  - 0002-9297 (Print)
IS  - 1537-6605 (Electronic)
IS  - 0002-9297 (Linking)
VI  - 64
IP  - 3
DP  - 1999 Mar
TI  - Evidence for a rare prostate cancer-susceptibility locus at chromosome 1p36.
PG  - 776-87
AB  - Combining data from a genomic screen in 70 families with a high risk for prostate 
      cancer (PC) with data from candidate-region mapping in these families and an 
      additional 71 families, we have localized a potential hereditary 
      PC-susceptibility locus to chromosome 1p36. Because an excess of cases of primary 
      brain cancer (BC) have been observed in some studies of families with a high risk 
      for PC, and because loss of heterozygosity at 1p36 is frequently observed in BC, 
      we further evaluated 12 families with both a history of PC and a blood relative 
      with primary BC. The overall LOD score in these 12 families was 3.22 at a 
      recombination fraction (theta) of .06, with marker D1S507. On the basis of an a 
      priori hypothesis, this group was stratified by age at diagnosis of PC. In the 
      younger age group (mean age at diagnosis <66 years), a maximum two-point LOD 
      score of 3.65 at straight theta = .0 was observed, with D1S407. This linkage was 
      rejected in both early- and late-onset families without a history of BC (LOD 
      scores -7.12 and -6.03, respectively, at straight theta = .0). After exclusion of 
      3 of the 12 families that had better evidence of linkage to previously described 
      PC-susceptibility loci, linkage to the 1p36 region was suggested by a two-point 
      LOD score of 4.74 at straight theta = .0, with marker D1S407. We conclude that a 
      significant proportion of these families with both a high risk for PC and a 
      family member with BC show linkage to the 1p36 region.
FAU - Gibbs, M
AU  - Gibbs M
AD  - Division of Clinical Research, Fred Hutchinson Cancer Research Center, D2-190, 
      Seattle, WA 98109-1024, USA.
FAU - Stanford, J L
AU  - Stanford JL
FAU - McIndoe, R A
AU  - McIndoe RA
FAU - Jarvik, G P
AU  - Jarvik GP
FAU - Kolb, S
AU  - Kolb S
FAU - Goode, E L
AU  - Goode EL
FAU - Chakrabarti, L
AU  - Chakrabarti L
FAU - Schuster, E F
AU  - Schuster EF
FAU - Buckley, V A
AU  - Buckley VA
FAU - Miller, E L
AU  - Miller EL
FAU - Brandzel, S
AU  - Brandzel S
FAU - Li, S
AU  - Li S
FAU - Hood, L
AU  - Hood L
FAU - Ostrander, E A
AU  - Ostrander EA
LA  - eng
GR  - R01 CA56678/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Hum Genet
JT  - American journal of human genetics
JID - 0370475
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Aged
MH  - Alleles
MH  - Brain Neoplasms/genetics
MH  - Chromosomes, Human, Pair 1/*genetics
MH  - Genetic Linkage
MH  - Genetic Markers
MH  - Genetic Predisposition to Disease
MH  - Genetic Testing
MH  - Humans
MH  - Lod Score
MH  - Loss of Heterozygosity/genetics
MH  - Male
MH  - Middle Aged
MH  - Pedigree
MH  - Penetrance
MH  - Prostatic Neoplasms/*genetics
PMC - PMC1377795
EDAT- 1999/03/03 03:04
MHDA- 2000/03/21 09:00
PMCR- 1999/09/01
CRDT- 1999/03/03 03:04
PHST- 1999/03/03 03:04 [pubmed]
PHST- 2000/03/21 09:00 [medline]
PHST- 1999/03/03 03:04 [entrez]
PHST- 1999/09/01 00:00 [pmc-release]
AID - S0002-9297(07)61715-7 [pii]
AID - 10.1086/302287 [doi]
PST - ppublish
SO  - Am J Hum Genet. 1999 Mar;64(3):776-87. doi: 10.1086/302287.