PMID- 1005741
OWN - NLM
STAT- MEDLINE
DCOM- 19770224
LR  - 20190823
IS  - 0090-6980 (Print)
IS  - 0090-6980 (Linking)
VI  - 12
IP  - 6
DP  - 1976 Dec
TI  - Arterial walls generate from prostaglandin endoperoxides a substance 
      (prostaglandin X) which relaxes strips of mesenteric and coeliac ateries and 
      inhibits platelet aggregation.
PG  - 897-913
AB  - Fresh arterial tissue generates an unstable substance (prostablandin X) which 
      relaxes vascular smooth muscle and potently inhibits platelet aggregation. The 
      release of prostaglandin (PG) X can be stimulated by incubation with arachidonic 
      acid or prostaglandin endoperoxides PGG2 or PGH2. The basal release of PGX or the 
      release stimulated with arachidonic acid can be inhibited by previous treatment 
      with indomethacin or by washing the tissue with a solution containing 
      indomethacin. The formation of PGX from prostaglandin endoperoxides PGG2 or PGH2 
      is not inhibited by indomethacin. 15-hydroperoxy arachidonic acid (15-HPAA) 
      inhibits the basal release of PGX as well as the release stimulated by 
      arachidonic acid or prostaglandin endoperoxides (PGG2 or PGH2). Fresh arterial 
      tissue obtained from control or indomethacin treated rabbits, when incubated with 
      platelet rich plasma (PRP) generates PGX. This generation is inhibited by 
      treating the tissue with 15-HPAA. A biochemical interaction between platelets and 
      vessel wall is postulated by which platelets feed the vessel wall with 
      prostaglandin endoperoxides which are utilized to form PGX. Formation of PGX 
      could be the underlying mechanism which actively prevents, under normal 
      conditions, the accumulation of platelets on the vessel wall.
FAU - Bunting, S
AU  - Bunting S
FAU - Gryglewski, R
AU  - Gryglewski R
FAU - Moncada, S
AU  - Moncada S
FAU - Vane, J R
AU  - Vane JR
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Prostaglandins
JT  - Prostaglandins
JID - 0320271
RN  - 0 (Arachidonic Acids)
RN  - 0 (Peroxides)
RN  - 0 (Prostaglandins F)
RN  - XXE1CET956 (Indomethacin)
SB  - IM
MH  - Animals
MH  - Arachidonic Acids/pharmacology
MH  - Celiac Artery/drug effects
MH  - Drug Interactions
MH  - Indomethacin/pharmacology
MH  - Mesenteric Arteries/drug effects
MH  - Muscle Contraction/*drug effects
MH  - Muscle, Smooth/*drug effects/metabolism
MH  - Peroxides/pharmacology
MH  - Platelet Aggregation/*drug effects
MH  - Prostaglandins F/metabolism/*pharmacology
MH  - Rabbits
MH  - Rats
MH  - Swine
EDAT- 1976/12/01 00:00
MHDA- 1976/12/01 00:01
CRDT- 1976/12/01 00:00
PHST- 1976/12/01 00:00 [pubmed]
PHST- 1976/12/01 00:01 [medline]
PHST- 1976/12/01 00:00 [entrez]
AID - 0090-6980(76)90125-8 [pii]
AID - 10.1016/0090-6980(76)90125-8 [doi]
PST - ppublish
SO  - Prostaglandins. 1976 Dec;12(6):897-913. doi: 10.1016/0090-6980(76)90125-8.