PMID- 10063324
OWN - NLM
STAT- MEDLINE
DCOM- 19990326
LR  - 20131121
IS  - 0391-1977 (Print)
IS  - 0391-1977 (Linking)
VI  - 23
IP  - 3
DP  - 1998 Sep
TI  - [Gliclazide and metformin combination in patients with type 2 diabetes. 
      Preliminary data].
PG  - 71-5
AB  - BACKGROUND: This preliminary study is aimed at the evaluation of the efficacy and 
      tolerability of combined therapy with gliclazide and metformin in the treatment 
      of patients with type 2 diabetes mellitus inadequately controlled with maximal 
      doses of gliclazide. METHODS: A prospective, uncontrolled study, with a follow-up 
      of 3 months, was performed in two Outpatient Diabetes Care Units. Fifty-seven 
      patients affected by type 2 diabetes for at least 5 years, aged 61.0 +/- 3.4 
      years, with a duration of diabetes of 9.2 +/- 3.9 years, Body Mass Index (BMI) 
      30.5 +/- 3.7 kg/m2, previously treated with gliclazide 240 mg/day, and with HbA1c 
      > 8.5%, were studied. The patients were treated with gliclazide 120 mg/day and 
      metformin 1500 mg/day for 3 months; HbA1c, 24-hour glycosuria, and fasting and 
      post-prandial glycaemia, were determined at the beginning and at the end of the 
      study. RESULTS: After a 3-month treatment, a reduction of fasting and 
      post-prandial glycaemia, glycosuria (15.0 +/- 5.3 versus 5.7 +/- 4.0 g/l, p < 
      0.01), and HbA1c (9.9 +/- 1.1 versus 8.4 +/- 1.0%, p < 0.01) was observed, while 
      no significant changes occurred in body weight. The treatment was generally well 
      tolerated. CONCLUSIONS: In conclusion, the combination of gliclazide and 
      metformin, which could theoretically show some advantages over the association of 
      glibenclamide and metformin with regards to lipid and haemorheologic profiles, 
      resulted to be effective and well tolerated in patients with type 2 diabetes 
      inadequately controlled with sulphonylurea monotherapy.
FAU - Galeone, F
AU  - Galeone F
AD  - Servizio Multizonale di Diabetologia e Malattie Metaboliche, Ospedale, Pescia, 
      Pistoia.
FAU - Fiore, G
AU  - Fiore G
FAU - Arcangeli, A
AU  - Arcangeli A
FAU - Mannucci, E
AU  - Mannucci E
LA  - ita
PT  - Clinical Trial
PT  - English Abstract
PT  - Journal Article
TT  - L'associazione di gliclazide e metformina in pazienti con diabete di tipo 2. Dati 
      preliminari.
PL  - Italy
TA  - Minerva Endocrinol
JT  - Minerva endocrinologica
JID - 8406505
RN  - 0 (Drug Combinations)
RN  - 0 (Hypoglycemic Agents)
RN  - 9100L32L2N (Metformin)
RN  - G4PX8C4HKV (Gliclazide)
SB  - IM
MH  - Diabetes Mellitus, Type 2/*drug therapy
MH  - Drug Combinations
MH  - Female
MH  - Gliclazide/*therapeutic use
MH  - Humans
MH  - Hypoglycemic Agents/*therapeutic use
MH  - Male
MH  - Metformin/*therapeutic use
MH  - Middle Aged
MH  - Prospective Studies
EDAT- 1999/03/04 00:00
MHDA- 1999/03/04 00:01
CRDT- 1999/03/04 00:00
PHST- 1999/03/04 00:00 [pubmed]
PHST- 1999/03/04 00:01 [medline]
PHST- 1999/03/04 00:00 [entrez]
PST - ppublish
SO  - Minerva Endocrinol. 1998 Sep;23(3):71-5.