PMID- 10063411
OWN - NLM
STAT- MEDLINE
DCOM- 19990309
LR  - 20161124
IS  - 1078-5884 (Print)
IS  - 1078-5884 (Linking)
VI  - 17
IP  - 2
DP  - 1999 Feb
TI  - Is there a relationship between abdominal aortic aneurysms and alpha1-antitrypsin 
      deficiency (PiZ)?
PG  - 149-54
AB  - OBJECTIVE: To determine if the frequency of alpha 1AT deficiency (PiZ) is 
      increased in patients with abdominal aortic aneurysm (AAA), and, to investigate 
      whether aneurysmal stiffness and other clinical characteristics differ in AAA 
      patients with and without alpha 1AT deficiency. METHODS: We identified alpha 
      1AT-deficient individuals by a monoclonal-antibody ELISA technique, in 102 
      consecutive patients with AAA. Positive ELISA samples were further phenotyped by 
      isoelectric focusing to differentiate between the heterozygosity (PiZ) and 
      homozygosity (PiZZ) state. Aneurysmal diameter and stiffness was measured using 
      echotracking sonography and blood pressure measurements. RESULTS: The frequency 
      of heterozygous alpha 1AT deficiency (PiZ) in patients with AAA was similar to 
      that in the general population (6.8% and 4.7%, respectively, p > 0.3). The 
      frequency of popliteal and femoral aneurysm was similar in male PiZ-carriers and 
      non-carriers with AAA, as were age at diagnosis of AAA, aneurysmal diameter, 
      aneurysmal stiffness, and presence of factors that may be associated with AAA 
      (i.e. smoking, hypertension, diabetes mellitus, and family history of AAA). 
      Occurrence of ischaemic heart disease was more frequent in male non-PiZ-carriers 
      than in male PiZ-carriers with AAA (p = 0.03). CONCLUSIONS: The frequency of 
      alpha 1AT deficiency (PiZ) was not increased in our series of patients with AAA 
      and patients in whom the two disorders coexisted did not appear to have different 
      clinical characteristics except for the lower occurrence of ischaemic heart 
      disease among the PiZ-carriers.
FAU - Elzouki, A N
AU  - Elzouki AN
AD  - Department of Medicine, University of Lund, Malmo University Hospital, Sweden.
FAU - Ryden Ahlgren, A
AU  - Ryden Ahlgren A
FAU - Lanne, T
AU  - Lanne T
FAU - Sonesson, B
AU  - Sonesson B
FAU - Eriksson, S
AU  - Eriksson S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur J Vasc Endovasc Surg
JT  - European journal of vascular and endovascular surgery : the official journal of 
      the European Society for Vascular Surgery
JID - 9512728
RN  - 0 (Antibodies, Monoclonal)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Antibodies, Monoclonal
MH  - Aortic Aneurysm, Abdominal/*complications/diagnostic imaging/*physiopathology
MH  - Blood Pressure
MH  - Enzyme-Linked Immunosorbent Assay/methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Sweden
MH  - Ultrasonography
MH  - Vasodilation
MH  - alpha 1-Antitrypsin Deficiency/*complications
EDAT- 1999/03/04 00:00
MHDA- 1999/03/04 00:01
CRDT- 1999/03/04 00:00
PHST- 1999/03/04 00:00 [pubmed]
PHST- 1999/03/04 00:01 [medline]
PHST- 1999/03/04 00:00 [entrez]
AID - S1078-5884(98)90740-7 [pii]
AID - 10.1053/ejvs.1998.0740 [doi]
PST - ppublish
SO  - Eur J Vasc Endovasc Surg. 1999 Feb;17(2):149-54. doi: 10.1053/ejvs.1998.0740.