PMID- 10064820
OWN - NLM
STAT- MEDLINE
DCOM- 19990413
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 821
IP  - 2
DP  - 1999 Mar 13
TI  - Cellular localization of brain-derived neurotrophic factor-like immunoreactivity 
      in adult monkey brain.
PG  - 341-9
AB  - Immunohistochemical localization of brain-derived neurotrophic factor (BDNF) in 
      the monkey brain was investigated using a polyclonal anti-BDNF antibody produced 
      in our laboratory. The antibody recognized a single band in monkey brain 
      homogenates, and the estimated molecular weight was approximately 14 kDa, which 
      corresponds well to the molecular weight of BDNF monomer. BDNF-like 
      immunoreactivity was observed in the somata and processes of discrete neuronal 
      subpopulations in the monkey brain. BDNF-positive neurons were widely distributed 
      in various structures of the brain, including the cerebral cortex, hippocampus, 
      basal forebrain, basal ganglia, diencephalon, brainstem and cerebellum. In 
      addition, immunopositive glial cells were found in some brain regions. These data 
      suggest that BDNF may exist widely in the monkey brain, and may be concerned with 
      various types of neurons in the monkey central nervous system.
CI  - Copyright 1999 Elsevier Science B.V.
FAU - Kawamoto, Y
AU  - Kawamoto Y
AD  - Department of Neurology, Faculty of Medicine, Kyoto University, Kyoto 606, Japan.
FAU - Nakamura, S
AU  - Nakamura S
FAU - Kawamata, T
AU  - Kawamata T
FAU - Akiguchi, I
AU  - Akiguchi I
FAU - Kimura, J
AU  - Kimura J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Antibodies)
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Antibodies
MH  - Basal Ganglia/chemistry/cytology
MH  - Blotting, Western
MH  - Brain Chemistry/*physiology
MH  - Brain Stem/chemistry/cytology
MH  - Brain-Derived Neurotrophic Factor/*analysis/immunology
MH  - Cerebellum/chemistry/cytology
MH  - Cerebral Cortex/chemistry/cytology
MH  - Hippocampus/chemistry/cytology
MH  - Hypothalamus/chemistry/cytology
MH  - Macaca
MH  - Neuroglia/chemistry
MH  - Neurons/*chemistry
MH  - Thalamus/chemistry/cytology
EDAT- 1999/03/05 00:00
MHDA- 1999/03/05 00:01
CRDT- 1999/03/05 00:00
PHST- 1999/03/05 00:00 [pubmed]
PHST- 1999/03/05 00:01 [medline]
PHST- 1999/03/05 00:00 [entrez]
AID - S0006-8993(99)01082-3 [pii]
AID - 10.1016/s0006-8993(99)01082-3 [doi]
PST - ppublish
SO  - Brain Res. 1999 Mar 13;821(2):341-9. doi: 10.1016/s0006-8993(99)01082-3.