PMID- 10066265
OWN - NLM
STAT- MEDLINE
DCOM- 19990413
LR  - 20191023
IS  - 0270-6474 (Print)
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Linking)
VI  - 19
IP  - 6
DP  - 1999 Mar 15
TI  - Brain-derived neurotrophic factor prevents low-frequency inputs from inducing 
      long-term depression in the developing visual cortex.
PG  - 2122-30
AB  - Brain-derived neurotrophic factor (BDNF) is reported to enhance synaptic 
      transmission and to play a role in long-term potentiation in hippocampus and 
      neocortex. If so, a shortage or blockade of BDNF might lead to another form of 
      synaptic plasticity, long-term depression (LTD). To test this possibility and to 
      elucidate mechanisms if it is the case, EPSCs evoked by test stimulation of layer 
      IV were recorded from layer II/III neurons in visual cortical slices of young 
      rats in the whole-cell voltage-clamp mode. LTD was induced by low-frequency 
      stimulation (LFS) at 1 Hz for 10-15 min if each pulse of the LFS was paired with 
      depolarization of neurons to -30 mV but was not induced if their membrane 
      potentials were kept at -70 mV. Such an LTD was blocked by exogenously applied 
      BDNF, probably through presynaptic mechanisms. Suppression of endogenous BDNF 
      activity by the anti-BDNF antibody or an inhibitor for BDNF receptors made 
      otherwise ineffective stimuli (LFS without postsynaptic depolarization) effective 
      for LTD induction, suggesting that endogenous BDNF may prevent low-frequency 
      inputs from inducing LTD in the developing visual cortex.
FAU - Kinoshita, S
AU  - Kinoshita S
AD  - Department of Neurophysiology, Biomedical Research Center, Osaka University 
      Medical School, Suita, 565-0871 Japan.
FAU - Yasuda, H
AU  - Yasuda H
FAU - Taniguchi, N
AU  - Taniguchi N
FAU - Katoh-Semba, R
AU  - Katoh-Semba R
FAU - Hatanaka, H
AU  - Hatanaka H
FAU - Tsumoto, T
AU  - Tsumoto T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Aging/*physiology
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/antagonists & 
      inhibitors/*pharmacology/physiology
MH  - Electric Stimulation/methods
MH  - Electrophysiology
MH  - In Vitro Techniques
MH  - Long-Term Potentiation/*physiology
MH  - Patch-Clamp Techniques
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Synapses/physiology
MH  - Visual Cortex/growth & development/*physiology
PMC - PMC6782543
EDAT- 1999/03/05 00:00
MHDA- 1999/03/05 00:01
PMCR- 1999/09/15
CRDT- 1999/03/05 00:00
PHST- 1999/03/05 00:00 [pubmed]
PHST- 1999/03/05 00:01 [medline]
PHST- 1999/03/05 00:00 [entrez]
PHST- 1999/09/15 00:00 [pmc-release]
AID - 2844 [pii]
AID - 10.1523/JNEUROSCI.19-06-02122.1999 [doi]
PST - ppublish
SO  - J Neurosci. 1999 Mar 15;19(6):2122-30. doi: 10.1523/JNEUROSCI.19-06-02122.1999.