PMID- 10066266
OWN - NLM
STAT- MEDLINE
DCOM- 19990413
LR  - 20231014
IS  - 0270-6474 (Print)
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Linking)
VI  - 19
IP  - 6
DP  - 1999 Mar 15
TI  - BDNF is a target-derived survival factor for arterial baroreceptor and 
      chemoafferent primary sensory neurons.
PG  - 2131-42
AB  - Brain-derived neurotrophic factor (BDNF) supports survival of 50% of visceral 
      afferent neurons in the nodose/petrosal sensory ganglion complex (NPG; Ernfors et 
      al., 1994a; Jones et al., 1994; Conover et al., 1995; Liu et al., 1995; Erickson 
      et al., 1996), including arterial chemoafferents that innervate the carotid body 
      and are required for development of normal breathing (Erickson et al., 1996). 
      However, the relationship between BDNF dependence of visceral afferents and the 
      location and timing of BDNF expression in visceral tissues is unknown. The 
      present study demonstrates that BDNF mRNA and protein are transiently expressed 
      in NPG targets in the fetal cardiac outflow tract, including baroreceptor regions 
      in the aortic arch, carotid sinus, and right subclavian artery, as well as in the 
      carotid body. The period of BDNF expression corresponds to the onset of sensory 
      innervation and to the time at which fetal NPG neurons are BDNF-dependent in 
      vitro. Moreover, baroreceptor innervation is absent in newborn mice lacking BDNF. 
      In addition to vascular targets, vascular afferents themselves express high 
      levels of BDNF, both during and after the time they are BDNF-dependent. However, 
      endogenous BDNF supports survival of fetal NPG neurons in vitro only under 
      depolarizing conditions. Together, these data indicate two roles for BDNF during 
      vascular afferent pathway development; initially, as a target-derived survival 
      factor, and subsequently, as a signaling molecule produced by the afferents 
      themselves. Furthermore, the fact that BDNF is required for survival of 
      functionally distinct populations of vascular afferents demonstrates that trophic 
      requirements of NPG neurons are not modality-specific but may instead be 
      associated with innervation of particular organ systems.
FAU - Brady, R
AU  - Brady R
AD  - Department of Neurosciences, Case Western Reserve University School of Medicine, 
      Cleveland, Ohio 44106-4975, USA.
FAU - Zaidi, S I
AU  - Zaidi SI
FAU - Mayer, C
AU  - Mayer C
FAU - Katz, D M
AU  - Katz DM
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (RNA, Messenger)
RN  - P658DCA9XD (neurotrophin 4)
SB  - IM
MH  - Animals
MH  - Arteries/*innervation
MH  - Blood Vessels/innervation/metabolism
MH  - Brain-Derived Neurotrophic Factor/genetics/metabolism/*physiology
MH  - Carotid Body/embryology
MH  - Cell Survival/physiology
MH  - Cells, Cultured
MH  - Chemoreceptor Cells/*physiology
MH  - Embryo, Mammalian/metabolism
MH  - Fetus/metabolism
MH  - Mice/genetics
MH  - Mutation/physiology
MH  - Nerve Growth Factors/genetics
MH  - Neurons, Afferent/*physiology
MH  - Pressoreceptors/*physiology
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Viscera/embryology/innervation
PMC - PMC6782548
EDAT- 1999/03/05 00:00
MHDA- 1999/03/05 00:01
PMCR- 1999/09/15
CRDT- 1999/03/05 00:00
PHST- 1999/03/05 00:00 [pubmed]
PHST- 1999/03/05 00:01 [medline]
PHST- 1999/03/05 00:00 [entrez]
PHST- 1999/09/15 00:00 [pmc-release]
AID - 2853 [pii]
AID - 10.1523/JNEUROSCI.19-06-02131.1999 [doi]
PST - ppublish
SO  - J Neurosci. 1999 Mar 15;19(6):2131-42. doi: 10.1523/JNEUROSCI.19-06-02131.1999.