PMID- 10066290
OWN - NLM
STAT- MEDLINE
DCOM- 19990413
LR  - 20220317
IS  - 0270-6474 (Print)
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Linking)
VI  - 19
IP  - 6
DP  - 1999 Mar 15
TI  - Dissociation in effects of lesions of the nucleus accumbens core and shell on 
      appetitive pavlovian approach behavior and the potentiation of conditioned 
      reinforcement and locomotor activity by D-amphetamine.
PG  - 2401-11
AB  - Dopamine release within the nucleus accumbens (NAcc) has been associated with 
      both the rewarding and locomotor-stimulant effects of abused drugs. The functions 
      of the NAcc core and shell were investigated in mediating amphetamine-potentiated 
      conditioned reinforcement and locomotion. Rats were initially trained to 
      associate a neutral stimulus (Pavlovian CS) with food reinforcement (US). After 
      excitotoxic lesions that selectively destroyed either the NAcc core or shell, 
      animals underwent additional CS-US training sessions and then were tested for the 
      acquisition of a new instrumental response that produced the CS acting as a 
      conditioned reinforcer (CR). Animals were infused intra-NAcc with D-amphetamine 
      (0, 1, 3, 10, or 20 microg) before each session. Shell lesions affected neither 
      Pavlovian nor instrumental conditioning but completely abolished the potentiative 
      effect of intra-NAcc amphetamine on responding with CR. Core-lesioned animals 
      were impaired during the Pavlovian retraining sessions but showed no deficit in 
      the acquisition of responding with CR. However, the selectivity in 
      stimulant-induced potentiation of the CR lever was reduced, as intra-NAcc 
      amphetamine infusions dose-dependently increased responding on both the CR lever 
      and a nonreinforced (control) lever. Shell lesions produced hypoactivity and 
      attenuated amphetamine-induced activity. In contrast, core lesions resulted in 
      hyperactivity and enhanced the locomotor-stimulating effect of amphetamine. These 
      results indicate a functional dissociation of subregions of the NAcc; the shell 
      is a critical site for stimulant effects underlying the enhancement of responding 
      with CR and locomotion after intra-NAcc injections of amphetamine, whereas the 
      core is implicated in mechanisms underlying the expression of CS-US associations.
FAU - Parkinson, J A
AU  - Parkinson JA
AD  - Department of Experimental Psychology, University of Cambridge, Cambridge, United 
      Kingdom CB2 3EB.
FAU - Olmstead, M C
AU  - Olmstead MC
FAU - Burns, L H
AU  - Burns LH
FAU - Robbins, T W
AU  - Robbins TW
FAU - Everitt, B J
AU  - Everitt BJ
LA  - eng
GR  - G9537855/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - TZ47U051FI (Dextroamphetamine)
SB  - IM
MH  - Animal Feed
MH  - Animals
MH  - Behavior, Animal/*physiology
MH  - Brain Mapping
MH  - Conditioning, Classical/drug effects/*physiology
MH  - Dextroamphetamine/*pharmacology
MH  - Male
MH  - Motor Activity/*drug effects
MH  - Nucleus Accumbens/*physiology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - *Reinforcement, Psychology
PMC - PMC6782569
EDAT- 1999/03/05 00:00
MHDA- 1999/03/05 00:01
PMCR- 1999/09/15
CRDT- 1999/03/05 00:00
PHST- 1999/03/05 00:00 [pubmed]
PHST- 1999/03/05 00:01 [medline]
PHST- 1999/03/05 00:00 [entrez]
PHST- 1999/09/15 00:00 [pmc-release]
AID - 2872 [pii]
AID - 10.1523/JNEUROSCI.19-06-02401.1999 [doi]
PST - ppublish
SO  - J Neurosci. 1999 Mar 15;19(6):2401-11. doi: 10.1523/JNEUROSCI.19-06-02401.1999.