PMID- 10067683
OWN - NLM
STAT- MEDLINE
DCOM- 19990527
LR  - 20190728
IS  - 0264-410X (Print)
IS  - 0264-410X (Linking)
VI  - 17
IP  - 7-8
DP  - 1999 Feb 26
TI  - Pathogenicity of tick-borne encephalitis virus isolated in Hokkaido, Japan in 
      mouse model.
PG  - 779-87
AB  - The pathogenic characteristics of tick-borne encephalitis (TBE) virus strain 
      (Oshima 5-10) isolated from a sentinel dog in Hokkaido, Japan, was compared by 
      use of a mouse model with several inoculation routes to other strains of TBE 
      virus (the Far Eastern subtype; Sofjin strain and the Western subtype; 
      Hochosterwitz strain) and TBE complex virus (Langat virus; TP-21 strain). The 
      degree of neuroinvasiveness of the strains in mice subcutaneously (s.c.) 
      inoculated was Sofjin equaled Hochosterwitz which was greater than Oshima and 
      TP-21, respectively. Neurovirulence, as determined after intracerebral 
      inoculation was Sofjin > Oshima = Hochosterwitz > TP-21. Virus replication in the 
      brains of mice s.c. or intracerebrally inoculated with Oshima strain was slower 
      and of lower titer than that of Sofjin strain. Histopathological findings 
      indicated that subarachnoid infiltration of mononuclear cells prior to necrosis 
      of the cerebrum was characteristic in Oshima strain. These findings indicated 
      that the Oshima strain possessed a pathogenic potential common to TBE viruses and 
      is less virulent for mice as compared with the two other TBE strains examined.
FAU - Chiba, N
AU  - Chiba N
AD  - Department of Environmental Veterinary Sciences, Graduate School of Veterinary 
      Medicine, Hokkaido University, Sapporo, Japan.
FAU - Iwasaki, T
AU  - Iwasaki T
FAU - Mizutani, T
AU  - Mizutani T
FAU - Kariwa, H
AU  - Kariwa H
FAU - Kurata, T
AU  - Kurata T
FAU - Takashima, I
AU  - Takashima I
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Vaccine
JT  - Vaccine
JID - 8406899
RN  - 0 (Antibodies, Viral)
SB  - IM
MH  - Animals
MH  - Antibodies, Viral/biosynthesis/blood
MH  - Brain/virology
MH  - Cell Line
MH  - Cricetinae
MH  - Disease Models, Animal
MH  - Dogs
MH  - Encephalitis Viruses, Tick-Borne/immunology/*isolation & 
      purification/*pathogenicity
MH  - Encephalitis, Tick-Borne/immunology/pathology/*virology
MH  - Japan
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Neutralization Tests
MH  - Virulence
MH  - Virus Replication/immunology
EDAT- 1999/03/06 00:00
MHDA- 1999/03/06 00:01
CRDT- 1999/03/06 00:00
PHST- 1999/03/06 00:00 [pubmed]
PHST- 1999/03/06 00:01 [medline]
PHST- 1999/03/06 00:00 [entrez]
AID - S0264-410X(98)00262-X [pii]
AID - 10.1016/s0264-410x(98)00262-x [doi]
PST - ppublish
SO  - Vaccine. 1999 Feb 26;17(7-8):779-87. doi: 10.1016/s0264-410x(98)00262-x.