PMID- 10067839
OWN - NLM
STAT- MEDLINE
DCOM- 19990323
LR  - 20181201
IS  - 0013-7227 (Print)
IS  - 0013-7227 (Linking)
VI  - 140
IP  - 3
DP  - 1999 Mar
TI  - Stimulation of central and systemic oxytocin release by histamine in the 
      paraventricular hypothalamic nucleus: evidence for an interaction with 
      norepinephrine.
PG  - 1158-64
AB  - Central histaminergic neurons have been implicated in the control of oxytocin 
      (OT) secretion in various physiological conditions, including parturition and 
      lactation. The present studies investigated whether histamine also influences the 
      central intranuclear release of OT, which is known to be important in the 
      activation of OT neurons, and the possible interaction of histamine with 
      norepinephrine in systemic and central OT release. Microdialysis probes were 
      placed immediately adjacent to the hypothalamic paraventricular nucleus (PVN) and 
      used for administration of artificial cerebrospinal fluid (ACSF) vehicle, ACSF 
      containing histamine, ACSF containing histamine in combination with a specific H1 
      or H2 histamine receptor antagonist, or ACSF containing histamine and the 
      alpha-adrenergic antagonist phentolamine. Dialysates and plasma were collected, 
      and OT concentrations were determined using RIA. Dialysis of the PVN with ACSF 
      containing histamine significantly increased the release of OT systemically and 
      centrally within the PVN. Furthermore, the increases in OT concentration in 
      dialysates and plasma were prevented by simultaneous administration of 
      chlorpheniramine (an H1 receptor antagonist) or ranitidine (an H2 receptor 
      antagonist) as well as by the adrenergic antagonist phentolamine. These data 
      demonstrate that histamine acts within the PVN to increase both systemic and 
      intranuclear release of OT. Furthermore, the increased OT release induced by 
      histamine is dependent upon stimulation of both H1 and H2 histaminergic receptors 
      and subsequent activation of alpha-noradrenergic receptors. These findings 
      suggest that histamine induces systemic and intranuclear OT release by 
      stimulating the release of norepinephrine.
FAU - Bealer, S L
AU  - Bealer SL
AD  - Department of Physiology, University of Tennessee, Memphis 38163, USA. 
      sbealer@physio1.utmem.edu
FAU - Crowley, W R
AU  - Crowley WR
LA  - eng
GR  - HD-20074/HD/NICHD NIH HHS/United States
GR  - HD-32156/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Endocrinology
JT  - Endocrinology
JID - 0375040
RN  - 0 (Histamine H1 Antagonists)
RN  - 0 (Histamine H2 Antagonists)
RN  - 3U6IO1965U (Chlorpheniramine)
RN  - 50-56-6 (Oxytocin)
RN  - 820484N8I3 (Histamine)
RN  - 884KT10YB7 (Ranitidine)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Animals
MH  - Chlorpheniramine/pharmacology
MH  - Female
MH  - Histamine/*pharmacology
MH  - Histamine H1 Antagonists/pharmacology
MH  - Histamine H2 Antagonists/pharmacology
MH  - Neurons/*drug effects/metabolism
MH  - Norepinephrine/*metabolism
MH  - Oxytocin/*metabolism
MH  - Paraventricular Hypothalamic Nucleus/*drug effects/metabolism
MH  - Ranitidine/pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Stimulation, Chemical
EDAT- 1999/03/06 00:00
MHDA- 1999/03/06 00:01
CRDT- 1999/03/06 00:00
PHST- 1999/03/06 00:00 [pubmed]
PHST- 1999/03/06 00:01 [medline]
PHST- 1999/03/06 00:00 [entrez]
AID - 10.1210/endo.140.3.6601 [doi]
PST - ppublish
SO  - Endocrinology. 1999 Mar;140(3):1158-64. doi: 10.1210/endo.140.3.6601.