PMID- 10069250
OWN - NLM
STAT- MEDLINE
DCOM- 19990422
LR  - 20071114
IS  - 1044-3983 (Print)
IS  - 1044-3983 (Linking)
VI  - 10
IP  - 2
DP  - 1999 Mar
TI  - Changing paternity and the risk of preterm delivery in the subsequent pregnancy.
PG  - 148-52
AB  - I studied whether changing a partner, and thus changing the likelihood of human 
      leukocyte antigen (HLA) sharing between mating partners, affects the risk of 
      preterm delivery in the subsequent pregnancy. I identified a total of 128,239 
      women who had two consecutive births during 1989-1991 through data linkage of the 
      California birth certificates. Paternal date of birth and names on the records of 
      the two consecutive births were compared to determine whether the same father was 
      reported on both records. Three cohorts of women were formed on the basis of the 
      gestational age of their first delivery: <34, 34-36, and >36 weeks. If parental 
      HLA sharing is associated with preterm delivery, the likelihood of HLA sharing 
      was expected to be in a decreasing order from most likely among a <34-week cohort 
      to least likely among a >36-week cohort. Among women in the <34-week cohort, 
      changing partners resulted in a 33% reduction in the risk of early preterm 
      delivery in the subsequent pregnancy compared with those who did not change 
      partners [95% confidence interval (CI), 0.52-0.88]. In contrast, among women in 
      the >36-week cohort, changing partners led to a 16% increase in the risk of early 
      preterm delivery in the subsequent pregnancy (95% CI = 1.04-1.30). Among women in 
      the 34-36-week cohort, changing partners did not affect the risk of preterm 
      delivery (95% CI = 0.78-1.25). These estimates were adjusted for maternal 
      race/ethnicity, age, educational level, prenatal smoking, prenatal care, parity, 
      and interval from birth to conception of the subsequent pregnancy. The findings 
      from this study suggest that the effect of changing paternity depends on the 
      pregnancy outcome with the previous partner and support the hypothesis that 
      parental HLA sharing may be related to preterm delivery.
FAU - Li, D K
AU  - Li DK
AD  - Division of Research, Kaiser Foundation Research Institute, Kaiser Permanente, 
      Oakland, CA 94611, USA.
LA  - eng
GR  - NICHD-CRMC-94-01/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Epidemiology
JT  - Epidemiology (Cambridge, Mass.)
JID - 9009644
SB  - IM
MH  - Adult
MH  - Female
MH  - *Histocompatibility
MH  - Histocompatibility Testing
MH  - Humans
MH  - *Obstetric Labor, Premature
MH  - *Paternity
MH  - Pregnancy/*immunology
EDAT- 1999/03/09 00:00
MHDA- 1999/03/09 00:01
CRDT- 1999/03/09 00:00
PHST- 1999/03/09 00:00 [pubmed]
PHST- 1999/03/09 00:01 [medline]
PHST- 1999/03/09 00:00 [entrez]
AID - 00001648-199903000-00008 [pii]
PST - ppublish
SO  - Epidemiology. 1999 Mar;10(2):148-52.