PMID- 10069285 OWN - NLM STAT- MEDLINE DCOM- 19990421 LR - 20190909 IS - 1053-0770 (Print) IS - 1053-0770 (Linking) VI - 13 IP - 1 DP - 1999 Feb TI - Heparin management test versus activated coagulation time during cardiovascular surgery: correlation with anti-Xa activity. PG - 53-7 AB - OBJECTIVE: To compare the abilities of the heparin management test (HMT) and the activated coagulation time (ACT) to provide a measurement of heparin effect in patients undergoing cardiac or peripheral vascular surgery. These measurements of heparin effect were also compared with measurements of heparin concentrations tested by anti-Xa activity. A secondary objective was to compare the performance of the noncitrated HMT with that of the citrated HMT. DESIGN: A prospective study. SETTING: A single-center study conducted in a university hospital. PARTICIPANTS: After human investigation committee approval and informed consent were obtained, adult patients undergoing cardiac or peripheral vascular surgery were included in this study. INTERVENTIONS: In both surgical groups, blood was sampled for ACT, HMT, and anti-Xa activity. Each HMT was performed on both noncitrated and citrated samples. MEASUREMENTS AND MAIN RESULTS: As an indicator of heparin effect, the HMT had a strong correlation with the ACT (r = 0.899; p < 0.01). In addition, the HMT had a significantly stronger correlation with anti-Xa activity than the ACT (p < 0.01). The correlation obtained from the noncitrated samples was identical with that obtained from the citrated samples (r = 0.819; p < 0.001 for both groups). CONCLUSION: The ability of the HMT and the ACT to measure heparin effect was similar. The HMT performed better than the ACT when using anti-Xa activity as a measure of heparin concentration. Noncitrated HMT results were similar to citrated HMT results, thus supporting the use of fresh whole blood for testing purposes. FAU - Fitch, J C AU - Fitch JC AD - Department of Anesthesiology, Yale University School of Medicine, Yale-New Haven Hospital, CT, USA. FAU - Geary, K L AU - Geary KL FAU - Mirto, G P AU - Mirto GP FAU - Byrne, D W AU - Byrne DW FAU - Hines, R L AU - Hines RL LA - eng PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - J Cardiothorac Vasc Anesth JT - Journal of cardiothoracic and vascular anesthesia JID - 9110208 RN - 0 (Anticoagulants) RN - 9005-49-6 (Heparin) RN - EC 3.4.21.6 (Factor Xa) SB - IM MH - Aged MH - Anticoagulants/*therapeutic use MH - *Blood Coagulation Tests MH - *Cardiac Surgical Procedures MH - Cardiopulmonary Bypass MH - Drug Monitoring/*methods MH - Factor Xa/*analysis MH - Female MH - Heparin/*therapeutic use MH - Humans MH - Male MH - Middle Aged MH - Prospective Studies MH - *Vascular Surgical Procedures MH - Whole Blood Coagulation Time EDAT- 1999/03/09 00:00 MHDA- 1999/03/09 00:01 CRDT- 1999/03/09 00:00 PHST- 1999/03/09 00:00 [pubmed] PHST- 1999/03/09 00:01 [medline] PHST- 1999/03/09 00:00 [entrez] AID - S1053-0770(99)90174-X [pii] AID - 10.1016/s1053-0770(99)90174-x [doi] PST - ppublish SO - J Cardiothorac Vasc Anesth. 1999 Feb;13(1):53-7. doi: 10.1016/s1053-0770(99)90174-x.