PMID- 10069768
OWN - NLM
STAT- MEDLINE
DCOM- 19990601
LR  - 20180213
IS  - 0301-0147 (Print)
IS  - 0301-0147 (Linking)
VI  - 28 Suppl 3
DP  - 1998
TI  - New perspectives for treatment of pulmonary embolism.
PG  - 95-9
AB  - Subcutaneous low-molecular-weight heparins (LMWHs) have been shown to be as safe 
      and effective as intravenous unfractionated heparin (UFH) for the initial 
      treatment of patients with deep vein thrombosis and acute symptomatic pulmonary 
      embolism. In comparison with UFH, LMWHs have a longer half-life, greater 
      bioavailability and more predictable antithrombotic effect when administered in 
      fixed doses, thus obviating the need for laboratory monitoring. It is therefore 
      feasible that LMWH preparations may replace UFH for the treatment of pulmonary 
      embolism in the future. It is recommended that LMWH should be administered for 
      5-10 days and should overlap with oral anticoagulant therapy by at least 4 days. 
      Surgical pulmonary embolectomy should only be considered in patients with 
      life-threatening pulmonary embolism who have failed to respond during the first 3 
      h of thrombolytic therapy. The systematic use of vena cava filters is not 
      recommended in patients presumed to be at high risk for pulmonary embolism.
FAU - Simonneau, G
AU  - Simonneau G
AD  - Service de Pneumologie et Centre de Maladies Vasculaires Pulmonaires, Hopital 
      Antoine Beclere, Clamart, France.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Switzerland
TA  - Haemostasis
JT  - Haemostasis
JID - 0371574
RN  - 0 (Anticoagulants)
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Anticoagulants/*administration & dosage
MH  - Heparin/*administration & dosage
MH  - Heparin, Low-Molecular-Weight/*administration & dosage
MH  - Humans
MH  - Injections, Intravenous
MH  - Injections, Subcutaneous
MH  - Pulmonary Embolism/*drug therapy
MH  - Thrombophlebitis/drug therapy
RF  - 9
EDAT- 1999/03/09 03:01
MHDA- 2000/10/06 11:01
CRDT- 1999/03/09 03:01
PHST- 1999/03/09 03:01 [pubmed]
PHST- 2000/10/06 11:01 [medline]
PHST- 1999/03/09 03:01 [entrez]
AID - hae8c095 [pii]
AID - 10.1159/000022412 [doi]
PST - ppublish
SO  - Haemostasis. 1998;28 Suppl 3:95-9. doi: 10.1159/000022412.