PMID- 10070234
OWN - NLM
STAT- MEDLINE
DCOM- 19990413
LR  - 20061115
IS  - 0040-5957 (Print)
IS  - 0040-5957 (Linking)
VI  - 53
IP  - 6
DP  - 1998 Nov-Dec
TI  - [Evaluation of the risk of venous thromboembolism in the medical patients].
PG  - 565-70
AB  - The venous thromboembolic risk seems to be demonstrated in medical patients since 
      the incidence of symptomatic and asymptomatic deep vein thrombosis (DVT) without 
      any prophylactic methods is respectively about 50 per cent in stroke, 25 per cent 
      in acute myocardial infarction (AMI) and 15 per cent in internal medicine. A 
      synthesis of clinical trials performed in medical patients shows that 
      prophylactic doses of heparins (unfractionated heparin or low molecular weight 
      heparins) reduce the incidence of DVT by 40 to 60 per cent compared with the lack 
      of any antithrombotic agents but without any significant effect on total 
      mortality. Other antithrombotic agents such as antiplatelet agents seem to reduce 
      the incidence of DVT by about 40 per cent associated with a significant decrease 
      in total mortality of stroke or AMI. But the recommendations made on the basis of 
      these results have to be extremely cautious since the number of medical patients 
      included in clinical trials is quite limited compared with the surgical area. 
      Moreover, each of these recommendations is not sufficiently proven. Thus more 
      clinical trials have to be carried out with a placebo control group in internal 
      medicine and an aspirin control group for stroke and AMI.
FAU - Mismetti, P
AU  - Mismetti P
AD  - Unite Pharmacologie Clinique, CHU Saint-Etienne Bellevue, France.
FAU - Juillard-Delsart, D
AU  - Juillard-Delsart D
FAU - Tardy, B
AU  - Tardy B
FAU - Laporte-Simitsidis, S
AU  - Laporte-Simitsidis S
FAU - Decousus, H
AU  - Decousus H
LA  - fre
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Evaluation du risque thromboembolique veineux en milieu medical.
PL  - France
TA  - Therapie
JT  - Therapie
JID - 0420544
RN  - 0 (Anticoagulants)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Anticoagulants/therapeutic use
MH  - Cerebrovascular Disorders/complications
MH  - Heparin/therapeutic use
MH  - Humans
MH  - Incidence
MH  - Internal Medicine
MH  - Myocardial Infarction/complications
MH  - Risk Factors
MH  - Thromboembolism/*epidemiology/*prevention & control
MH  - Venous Thrombosis/*epidemiology/*prevention & control
RF  - 14
EDAT- 1999/03/10 00:00
MHDA- 1999/03/10 00:01
CRDT- 1999/03/10 00:00
PHST- 1999/03/10 00:00 [pubmed]
PHST- 1999/03/10 00:01 [medline]
PHST- 1999/03/10 00:00 [entrez]
PST - ppublish
SO  - Therapie. 1998 Nov-Dec;53(6):565-70.