PMID- 10071162
OWN - NLM
STAT- MEDLINE
DCOM- 19990324
LR  - 20190921
IS  - 1395-3907 (Print)
IS  - 1395-3907 (Linking)
VI  - 77
IP  - 1
DP  - 1999 Feb
TI  - Antibiotic-induced endotoxemia in a patient with endogenous endophthalmitis.
PG  - 110-3
AB  - PURPOSE: The aim of the study is to describe a case of suspected 
      endotoxin-induced uveitis associated with septic endogenous endophthalmitis 
      followed by antibiotic-induced endotoxemia. METHODS: The human leukocyte antigen 
      (HLA) typing of peripheral leukocytes was studied by lymphocytotoxicity 
      technique. Histological and immunohistochemical studies of paraffin embedded 
      specimen were conducted. RESULTS: Findings of HLA typing revealed positive 
      reaction for B 51, Cw 3, DR 8, DR 11, DQ 3. The vitreous body of an eviscerated 
      eye was occupied by the non-specific granulomatous tissue, composed of 
      fibroblast, plasma cells, and Sudan black staining positive foamy cells, 
      including melaniferous phagocytes, identified as CD 68 positive macrophage. 
      CONCLUSION: It is suggested that antibiotic-induced endotoxemia of a patient with 
      septic endogenous endophthalmitis produced endotoxin-induced uveitis under an 
      upregulation of HLA and endotoxin activated macrophages may release cytokines, 
      followed by fibrin formation and subsequent granuloma.
FAU - Yamada, R
AU  - Yamada R
AD  - Department of Ophthalmology, St. Marianna University School of Medicine, 
      Kawasaki-shi, Japan.
FAU - Aida, Y
AU  - Aida Y
FAU - Kakimoto, S
AU  - Kakimoto S
FAU - Ueno, S
AU  - Ueno S
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Denmark
TA  - Acta Ophthalmol Scand
JT  - Acta ophthalmologica Scandinavica
JID - 9507578
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Endotoxins)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Aged
MH  - *Anti-Bacterial Agents
MH  - Cytotoxicity Tests, Immunologic
MH  - Drug Therapy, Combination/*adverse effects
MH  - Endophthalmitis/diagnosis/drug therapy/*microbiology
MH  - Endotoxemia/*chemically induced/diagnosis
MH  - Endotoxins/adverse effects
MH  - Eye Enucleation
MH  - Eye Infections, Bacterial/diagnosis/drug therapy/*microbiology
MH  - Female
MH  - Follow-Up Studies
MH  - Histocompatibility Antigens Class I/analysis
MH  - Histocompatibility Antigens Class II/analysis
MH  - Histocompatibility Testing
MH  - Humans
MH  - Klebsiella Infections/diagnosis/drug therapy/*microbiology
MH  - Klebsiella pneumoniae/immunology/isolation & purification
MH  - Leukocytes/immunology
MH  - Tomography, X-Ray Computed
EDAT- 1999/03/10 00:00
MHDA- 1999/03/10 00:01
CRDT- 1999/03/10 00:00
PHST- 1999/03/10 00:00 [pubmed]
PHST- 1999/03/10 00:01 [medline]
PHST- 1999/03/10 00:00 [entrez]
AID - 10.1034/j.1600-0420.1999.770125.x [doi]
PST - ppublish
SO  - Acta Ophthalmol Scand. 1999 Feb;77(1):110-3. doi: 
      10.1034/j.1600-0420.1999.770125.x.