PMID- 10071752
OWN - NLM
STAT- MEDLINE
DCOM- 19990615
LR  - 20220227
IS  - 1079-9893 (Print)
IS  - 1079-9893 (Linking)
VI  - 19
IP  - 1-4
DP  - 1999 Jan-Jul
TI  - Regulation of protein kinase B.
PG  - 121-8
AB  - Protein kinase B (PKB) is a member of the second-messenger regulated subfamily of 
      protein kinases implicated in signalling downstream of growth factor and insulin 
      receptor tyrosine kinases and phosphatidylinositol 3-kinase (PI 3-kinase). PKB is 
      activated by phosphorylation in response to mitogens and survival factors. 
      Membrane recruitment driven by lipid second-messengers derived from PI 3-kinase 
      leads to PKB phosphorylation and activation by upstream kinases (PDK1 and an as 
      yet identified protein kinase). Prolonged stimulation with growth factors results 
      in nuclear translocation, providing evidence that PKB activation at the plasma 
      membrane precedes its nuclear translocation and supporting a role for PKB in 
      signalling from receptor tyrosine kinases to the nucleus.
FAU - Meier, R
AU  - Meier R
AD  - Friedrich Miescher Institute, Basel, Switzerland.
FAU - Hemmings, B A
AU  - Hemmings BA
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - J Recept Signal Transduct Res
JT  - Journal of receptor and signal transduction research
JID - 9509432
RN  - 0 (Proto-Oncogene Proteins)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
SB  - IM
MH  - Animals
MH  - Enzyme Activation
MH  - Humans
MH  - Phosphorylation
MH  - *Protein Serine-Threonine Kinases
MH  - Proto-Oncogene Proteins/*metabolism
MH  - Proto-Oncogene Proteins c-akt
MH  - Second Messenger Systems
MH  - Signal Transduction
RF  - 29
EDAT- 1999/03/11 00:00
MHDA- 1999/03/11 00:01
CRDT- 1999/03/11 00:00
PHST- 1999/03/11 00:00 [pubmed]
PHST- 1999/03/11 00:01 [medline]
PHST- 1999/03/11 00:00 [entrez]
AID - 10.3109/10799899909036639 [doi]
PST - ppublish
SO  - J Recept Signal Transduct Res. 1999 Jan-Jul;19(1-4):121-8. doi: 
      10.3109/10799899909036639.