PMID- 10072368
OWN - NLM
STAT- MEDLINE
DCOM- 19990524
LR  - 20190921
IS  - 0959-4388 (Print)
IS  - 0959-4388 (Linking)
VI  - 9
IP  - 1
DP  - 1999 Feb
TI  - Neurotrophin regulation of synaptic transmission.
PG  - 105-9
AB  - Examples of signaling molecules that are devoted to neuronal development at the 
      exclusion of other functions are scarce. It may then come as no surprise to learn 
      that a family of molecules that promote neuronal survival, differentiation and 
      outgrowth also regulate synaptic transmission at both developing and mature 
      synapses. Indeed, many studies over the past five years have shown that 
      neurotrophins, including nerve growth factor (NGF), neurotrophin-3 (NT-3), NT-4/5 
      and brain-derived neurotrophic factor (BDNF), have both rapid and long-latency 
      influences on synaptic strength. New research has highlighted the enormous range 
      of neurotrophin actions at both developing and mature synapses, demonstrating 
      that transmission can be enhanced or reduced at excitatory and inhibitory 
      synapses by either pre- or postsynaptic mechanisms.
FAU - Schuman, E M
AU  - Schuman EM
AD  - Howard Hughes Medical Institute Division of Biology 216-76 Caltech Pasadena 
      California 91125 USA. schumane@cco.caltech.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Curr Opin Neurobiol
JT  - Current opinion in neurobiology
JID - 9111376
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/physiology
MH  - Mice
MH  - Mice, Knockout
MH  - Nerve Growth Factors/*physiology
MH  - Neuronal Plasticity
MH  - Synaptic Transmission/*physiology
RF  - 45
EDAT- 1999/03/11 00:00
MHDA- 1999/03/11 00:01
CRDT- 1999/03/11 00:00
PHST- 1999/03/11 00:00 [pubmed]
PHST- 1999/03/11 00:01 [medline]
PHST- 1999/03/11 00:00 [entrez]
AID - S0959-4388(99)80013-0 [pii]
AID - 10.1016/s0959-4388(99)80013-0 [doi]
PST - ppublish
SO  - Curr Opin Neurobiol. 1999 Feb;9(1):105-9. doi: 10.1016/s0959-4388(99)80013-0.