PMID- 10072701
OWN - NLM
STAT- MEDLINE
DCOM- 19990427
LR  - 20171116
IS  - 1043-6618 (Print)
IS  - 1043-6618 (Linking)
VI  - 39
IP  - 2
DP  - 1999 Feb
TI  - Magnoliae flos inhibits mast cell-dependent immediate-type allergic reactions.
PG  - 107-11
AB  - The mast cell plays a pivotal role in initiating allergic response by secreting 
      intracytoplasmic granular mediators such as histamine. Magnoliae flos has been 
      used for the treatment of allergic disease in Korea. However, its effect in 
      experimental models remains unknown. The present report describes an inhibitory 
      effect of Magnoliae flos on mast cell-mediated immediate-type allergic reactions. 
      Topical application of compound 48/80 can induce an ear swelling response in 
      normal (WBB6F1-+/+) mice but not in the congenic mast cell-deficient WBB6F1-W/Wv 
      mice. Magnoliae flos inhibited concentration-dependently mast cell-dependent ear 
      swelling response induced by compound 48/80 by topical application. Magnoliae 
      flos inhibited concentration-dependently passive cutaneous anaphylaxis induced by 
      anti-dinitrophenyl (DNP) IgE in rats by topical application. Magnoliae flos also 
      inhibited concentration-dependently the histamine release from the rat peritoneal 
      mast cells by compound 48/80 or anti-DNP IgE. Moreover, Magnoliae flos had a 
      significant inhibitory effect on compound 48/80-induced systemic anaphylactic 
      reaction. These results indicate that Magnoliae flos inhibits immediate-type 
      allergic reactions by inhibition of mast cell degranulation in vivo and in vitro.
CI  - Copyright 1999 The Italian Pharmacological Society.
FAU - Kim, H M
AU  - Kim HM
AD  - College of Pharmacy, Wonkwang University, Iksan, Chonbuk, 570-749, South Korea.
FAU - Yi, J M
AU  - Yi JM
FAU - Lim, K S
AU  - Lim KS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Pharmacol Res
JT  - Pharmacological research
JID - 8907422
RN  - 0 (Dinitrobenzenes)
RN  - 0 (Plant Extracts)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 4091-50-3 (p-Methoxy-N-methylphenethylamine)
SB  - IM
MH  - Anaphylaxis/chemically induced/immunology
MH  - Animals
MH  - Cattle
MH  - Dinitrobenzenes/immunology/toxicity
MH  - Edema/chemically induced/immunology
MH  - Histamine Release/drug effects
MH  - Humans
MH  - Hypersensitivity, Immediate/*immunology/pathology
MH  - Immunoglobulin E/immunology
MH  - Magnoliopsida/*chemistry
MH  - Mast Cells/*immunology
MH  - Mice
MH  - Passive Cutaneous Anaphylaxis/drug effects
MH  - Plant Extracts/pharmacology
MH  - Rats
MH  - p-Methoxy-N-methylphenethylamine/toxicity
EDAT- 1999/03/12 00:00
MHDA- 1999/03/12 00:01
CRDT- 1999/03/12 00:00
PHST- 1999/03/12 00:00 [pubmed]
PHST- 1999/03/12 00:01 [medline]
PHST- 1999/03/12 00:00 [entrez]
AID - S1043-6618(98)90414-5 [pii]
AID - 10.1006/phrs.1998.0414 [doi]
PST - ppublish
SO  - Pharmacol Res. 1999 Feb;39(2):107-11. doi: 10.1006/phrs.1998.0414.