PMID- 10073336
OWN - NLM
STAT- MEDLINE
DCOM- 19990422
LR  - 20190909
IS  - 0388-1350 (Print)
IS  - 0388-1350 (Linking)
VI  - 24
IP  - 1
DP  - 1999 Feb
TI  - Mechanism of weight gain suppressing effect of ER-40133, an angiotensin I 
      converting enzyme inhibitor, in growing rats.
PG  - 45-53
AB  - Effects of ER-40133, an inhibitor of angiotensin converting enzyme (ACE), on 
      weight gain and sodium and potassium balance were studied in growing SD male 
      rats. Thirty-two animals (seven weeks of age) were divided into two groups; one 
      received a standard diet containing 0.227% sodium and the other a low (0.065%) 
      sodium diet. They were divided into four subgroups; one control group and three 
      treated groups receiving 3, 10 or 30 mg/kg of ER-40133, by gavage, once a day for 
      five consecutive days. Body weight gain (average of the standard and low sodium 
      diet groups) was -32% in the 3 mg/kg group,-74% in 10 mg/kg group and -99% in 30 
      mg/kg group, when compared with the control group. There was a highly linear 
      correlation between suppression of body weight gain and reduction in sodium and 
      potassium retention for both groups of animals given the standard and low sodium 
      diet. The reduced sodium retention, the primary effect of ACE inhibitors, 
      accounted for about 30% of suppressed weight gain, and the reduced potassium 
      retention, the secondary effect of sodium deficiency, could account for the rest 
      about 70% of weight suppression by ER-40133.
FAU - Toritsuka, N
AU  - Toritsuka N
AD  - Drug Safety Research Laboratories, Eisai Co., Ltd., Ibaraki, Japan.
FAU - Tsukidate, K
AU  - Tsukidate K
FAU - Igarashi, T
AU  - Igarashi T
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - J Toxicol Sci
JT  - The Journal of toxicological sciences
JID - 7805798
RN  - 0 (Angiotensin-Converting Enzyme Inhibitors)
RN  - 0 (Azepines)
RN  - 0 (ER 40133)
RN  - 0 (Thiazoles)
RN  - 9NEZ333N27 (Sodium)
RN  - EC 3.4.24.11 (Neprilysin)
RN  - RWP5GA015D (Potassium)
SB  - IM
MH  - Angiotensin-Converting Enzyme Inhibitors/*toxicity
MH  - Animals
MH  - Azepines/*toxicity
MH  - Eating/drug effects
MH  - Male
MH  - Neprilysin/*antagonists & inhibitors
MH  - Potassium/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Sodium/metabolism
MH  - Thiazoles/*toxicity
MH  - Weight Gain/*drug effects
EDAT- 1999/03/12 00:00
MHDA- 1999/03/12 00:01
CRDT- 1999/03/12 00:00
PHST- 1999/03/12 00:00 [pubmed]
PHST- 1999/03/12 00:01 [medline]
PHST- 1999/03/12 00:00 [entrez]
AID - 10.2131/jts.24.45 [doi]
PST - ppublish
SO  - J Toxicol Sci. 1999 Feb;24(1):45-53. doi: 10.2131/jts.24.45.