PMID- 10074220
OWN - NLM
STAT- MEDLINE
DCOM- 19990414
LR  - 20131121
IS  - 1000-6834 (Print)
IS  - 1000-6834 (Linking)
VI  - 13
IP  - 2
DP  - 1997 May
TI  - [Changes of [Ca2+]i in colorectal cancer cells induced by some chemicals].
PG  - 97-101
AB  - Changes of [Ca2+]i in CCL229 cells induced by retionoic acid (RA), 1,25(OH)2VD3 
      and PMA were measured by spectrofluorometry. The effects of endoplasmic reticulum 
      (ER)-specific Ca(2+)-ATPase inhibitor thapsigargin (TG) and IP3 receptor 
      inhibitor heparin on RA-induced changes of [Ca2+]i were observed and the 
      relationship between RA-induced changes of [Ca2+]i and ER was also investigated. 
      The results showed that [Ca2+]i increased markedly in several seconds after 
      treated by RA and 1,25(OH)2VD3. When cells were pretreated with EGTA and 
      verapamil (Ca2+ entry blocker drug), TG could not inhibit RA-stimulated Ca2+ 
      release from intracellular calcium pools and TG could increase [Ca2+]i after 
      pretreated by RA. In addition, heparin could not completely inhibit RA-induced 
      [Ca2+]i increase. The results suggest that RA might stimulate IP3-sensitive pool 
      or IP3-insensitive pool on ER to increase [Ca2+]i, or there might be RA-sensitive 
      calcium pools except ER in cells.
FAU - Wang, H
AU  - Wang H
AD  - Key Laboratory of Cell Biology Ministry of Public Health of China, China Medical 
      University.
FAU - Song, J
AU  - Song J
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Ying Yong Sheng Li Xue Za Zhi
JT  - Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = 
      Chinese journal of applied physiology
JID - 9426407
RN  - 0 (Antineoplastic Agents)
RN  - 5688UTC01R (Tretinoin)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Antineoplastic Agents/pharmacology
MH  - Calcium/*metabolism
MH  - Cell Transformation, Neoplastic/drug effects
MH  - Colorectal Neoplasms/*metabolism/pathology
MH  - Endoplasmic Reticulum/metabolism
MH  - Humans
MH  - Tretinoin/pharmacology
MH  - Tumor Cells, Cultured
EDAT- 1997/05/01 00:00
MHDA- 1999/03/13 00:01
CRDT- 1997/05/01 00:00
PHST- 1997/05/01 00:00 [pubmed]
PHST- 1999/03/13 00:01 [medline]
PHST- 1997/05/01 00:00 [entrez]
PST - ppublish
SO  - Zhongguo Ying Yong Sheng Li Xue Za Zhi. 1997 May;13(2):97-101.