PMID- 10074781
OWN - NLM
STAT- MEDLINE
DCOM- 19990329
LR  - 20190905
IS  - 0079-6123 (Print)
IS  - 0079-6123 (Linking)
VI  - 119
DP  - 1998
TI  - Osmoregulation of vasopressin neurons: a synergy of intrinsic and synaptic 
      processes.
PG  - 59-76
AB  - The release of vasopressin into the general circulation varies as a function of 
      plasma osmolality and therefore plays a major role in systemic osmoregulation. In 
      vivo, the secretion of this hormone in the neurohypophysis is primarily 
      determined by the rate of action potential discharge of the magnocellular 
      neurosecretory cells (MNCs) in the hypothalamus. Experiments done over the past 
      20 years have clarified much of the neurophysiological basis underlying this 
      important osmoregulatory reflex. As discussed here, recent findings indicate that 
      the regulation of the firing rate of MNCs during changes in systemic osmolality 
      involves the concerted modulation of mechanosensitive ion channels in MNCs, as 
      well as excitatory glutamatergic inputs derived from forebrain regions such as 
      the organum vasculosum of the lamina terminalis.
FAU - Bourque, C W
AU  - Bourque CW
AD  - Centre for Research in Neuroscience, Montreal General Hospital, QC, Canada.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Prog Brain Res
JT  - Progress in brain research
JID - 0376441
RN  - 11000-17-2 (Vasopressins)
SB  - IM
MH  - Action Potentials/physiology
MH  - Animals
MH  - Mammals
MH  - Neurons/*physiology
MH  - Synapses/*physiology
MH  - Vasopressins/*physiology
MH  - Water-Electrolyte Balance/*physiology
RF  - 120
EDAT- 1999/03/13 00:00
MHDA- 1999/03/13 00:01
CRDT- 1999/03/13 00:00
PHST- 1999/03/13 00:00 [pubmed]
PHST- 1999/03/13 00:01 [medline]
PHST- 1999/03/13 00:00 [entrez]
AID - S0079-6123(08)61562-9 [pii]
AID - 10.1016/s0079-6123(08)61562-9 [doi]
PST - ppublish
SO  - Prog Brain Res. 1998;119:59-76. doi: 10.1016/s0079-6123(08)61562-9.