PMID- 10076865
OWN - NLM
STAT- MEDLINE
DCOM- 19990506
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 262
IP  - 1
DP  - 1999 Feb 26
TI  - The neurotrophins NGF and NT-3 reduce sensory neuronal loss in adult rat after 
      peripheral nerve lesion.
PG  - 29-32
AB  - The effect of three different neurotrophins on axotomy-induced death of adult rat 
      sensory neurons was examined. The ventral branch of the 13th spinal nerve was 
      transected and the corresponding neurons in the 13th thoracic (T13) dorsal root 
      ganglion (DRG) were pre-labelled with Fast Blue (FB). For a period of 4 weeks, 
      animals received either no treatment, continuous intrathecal infusion of 
      phosphate buffer, nerve growth factor (NGF), neurotrophin-3 (NT-3), or 
      brain-derived neurotrophic factor (BDNF). Labelled neurons remaining after this 
      period were counted. Inert, or no treatment, resulted in extensive loss of the 
      DRG neurons. BDNF application was virtually non-effective, while NGF or NT-3 
      resulted in a greater number of FB-labelled neurons compared to normal controls. 
      This suggests that NGF and NT-3 are survival factors for adult sensory neurons 
      with a therapeutic potential in peripheral nerve injuries.
FAU - Ljungberg, C
AU  - Ljungberg C
AD  - Department of Anatomy, Umea University, and University Hospital, Sweden.
FAU - Novikov, L
AU  - Novikov L
FAU - Kellerth, J O
AU  - Kellerth JO
FAU - Ebendal, T
AU  - Ebendal T
FAU - Wiberg, M
AU  - Wiberg M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Neurotrophin 3)
SB  - IM
MH  - Animals
MH  - Axotomy
MH  - Brain-Derived Neurotrophic Factor/administration & dosage
MH  - Cell Death/drug effects
MH  - Female
MH  - Infusion Pumps
MH  - Injections, Spinal
MH  - Nerve Growth Factors/administration & dosage/pharmacology/*therapeutic use
MH  - Neurons, Afferent/drug effects/*pathology
MH  - Neurotrophin 3
MH  - Peripheral Nerves/drug effects/*physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 1999/03/17 00:00
MHDA- 1999/03/17 00:01
CRDT- 1999/03/17 00:00
PHST- 1999/03/17 00:00 [pubmed]
PHST- 1999/03/17 00:01 [medline]
PHST- 1999/03/17 00:00 [entrez]
AID - S0304-3940(99)00040-3 [pii]
AID - 10.1016/s0304-3940(99)00040-3 [doi]
PST - ppublish
SO  - Neurosci Lett. 1999 Feb 26;262(1):29-32. doi: 10.1016/s0304-3940(99)00040-3.