PMID- 10077403
OWN - NLM
STAT- MEDLINE
DCOM- 19990603
LR  - 20190816
IS  - 0167-5273 (Print)
IS  - 0167-5273 (Linking)
VI  - 68
IP  - 1
DP  - 1999 Jan
TI  - Intense acute phase response in ischemic patients.
PG  - 69-73
AB  - The aim of this study was to estimate the qualitative and quantitative changes of 
      acute phase proteins in patients suffering from coronary heart disease. The study 
      was carried out on 74 patients and 12 healthy volunteers. The patients were 
      divided into three groups as follows: patients with myocardial infarction (n=37), 
      Group I--without heart failure, Group II--with heart failure (II-III NYHA), Group 
      III--patients with unstable angina pectoris (n=35); controls-healthy volunteers 
      (n=12). The immunological measurements were performed at the beginning of 
      hospitalisation (point 0), after 4, 8, 12 and 72 h, and after 6, 9 and 12 days of 
      hospitalisation. The concentrations of C-reactive protein (CRP), alpha1-acid 
      glycoprotein (AGP) and alpha1-antichymotrypsin (ACT) were measured using rocket 
      immunoelectrophoresis according to Laurell. Glycosylation profiles of AGP and ACT 
      were determined using crossed affinity immunoelectrophoresis with Con A as ligand 
      according to Bog-Hansen. Between Groups I and II statistically significant 
      differences were observed for all investigated parameters. Highest concentration 
      values were observed for Groups II and III; for Group II they appeared earlier 
      than for Group III. The maximal values for reactivity coefficients (AGP-RC and 
      ACT-RC) were observed earlier than the respective maximal values of 
      concentrations. Continuous activation occurring in unstable angina leads to a 
      more rapid increase in the concentrations of acute phase proteins and more marked 
      alterations in their glycosylation profiles. In a way these patients seem to be 
      'primed' with constant stimulation, so that they respond dramatically to the 
      stimulus of ischemia.
FAU - Kazmierczak, E
AU  - Kazmierczak E
AD  - Department of Clinical Pharmacology, University of Medical Sciences, Poznan, 
      Poland.
FAU - Sobieska, M
AU  - Sobieska M
FAU - Kazmierczak, M
AU  - Kazmierczak M
FAU - Mrozikiewicz, A
AU  - Mrozikiewicz A
FAU - Wiktorowicz, K
AU  - Wiktorowicz K
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
RN  - 0 (Acute-Phase Proteins)
SB  - IM
MH  - Acute-Phase Proteins/*metabolism
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Analysis of Variance
MH  - Angina, Unstable/*metabolism
MH  - Female
MH  - Heart Failure/etiology/*metabolism
MH  - Humans
MH  - Immunoelectrophoresis
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/complications/*metabolism
EDAT- 1999/03/17 00:00
MHDA- 1999/03/17 00:01
CRDT- 1999/03/17 00:00
PHST- 1999/03/17 00:00 [pubmed]
PHST- 1999/03/17 00:01 [medline]
PHST- 1999/03/17 00:00 [entrez]
AID - S0167527398003404 [pii]
AID - 10.1016/s0167-5273(98)00340-4 [doi]
PST - ppublish
SO  - Int J Cardiol. 1999 Jan;68(1):69-73. doi: 10.1016/s0167-5273(98)00340-4.